Natural modulator of mu-, delta-, and kappa-opioid receptors

Norepinephrine-dopamine reuptake inhibitor (NDRI)

Cholecystokinin antagonist, selective for the CCKA subtype

Glucocorticoid, Anti-inflammatory Agent

Pro-drug of dexamethasone, anti-inflammatory glucocorticoid, stimulating glutamine uptake in the cerebral cortex

Cysteine reactive protein labeling agent

PET precursor of preparing radiolabel [11C]HD-800, a high affinity brain penetrant PET tracer for imaging microtubules

Primary metabolite of diazepam, binding to the GABA A receptor benzodiazepine modulatory site

Precursor for PET imaging 11C-radiolabeled MK-6884

Desfluoro impurity of Ezetimibe

Inhibitor of acetyl-CoA carboxylase (ACC), activating GPR40, inhibiting West Nile virus (WNV) infection and reducing the multiplication of Usutu virus (USUV), a WNV-related flavivirus

HIV-1 fusion inhibitor, targeting the membrane-proximal external region of Env spikes, specifically inhibiting the HIV-1 envelope-mediated membrane fusion by blocking CD4-induced conformational changes

Most efficient spin trap for the in vitro and in vivo detection of O-, N-, S- and C-centered free radicals

Selective anti-tumor agent, inducing apoptosis and inhibiting topoisomerase I

Novel selective and sensitive near-infrared fluorescent probe for visualization of endogenous nitric oxide in living cells and animals

Novel reversible microtubule inhibitor, increasing lysosomal V-ATPase activity and lysosome acidity

Novel selective inhibitor of the DENV2 protease, inhibiting flavivirus protease through targeted covalent modification of active site serine, contrary to an allosteric binding mechanism as previously described

Novel selective inhibitor of the DENV2 protease, inhibiting flavivirus protease through targeted covalent modification of active site serine, contrary to an allosteric binding mechanism as previously described

Novel selective inhibitor of the DENV2 protease, inhibiting flavivirus protease through targeted covalent modification of active site serine, contrary to an allosteric binding mechanism as previously described

Novel anti-Alzheimer's disease agent, ameliorates spinal cord injury via axonal growth associated with astrocyte-secreted vimentin

Antispasmodic agent, improving the elasticity of the soft birth canal and regulating labor contractions

Selective DPP-IV Inhibitor

Potent inhibitor of PI3 kinases

Vitamin E variant, inhibiting prostate adenocarcinoma, lung tumorigenesis, promoting thermogenic gene expression via PGC-1α upregulation, preventing methylglyoxal-induced apoptosis by reducing ROS generation and inhibiting apoptotic signaling cascades

Novel selective δ-protein kinase C inhibitor

Natural polyketide matabolite

Novel selective degrader of BCR-ABL over c-ABL in leukemia cancer cells

Iron chelating agent, chelating iron from intra-lysosomal ferritin and hemosiderin forming ferrioxamine, a water-soluble chelate excreted by the kidneys and in the feces via the bile

Deferasirox iron complex

Novel potent inhibitor of the enoyl-acyl carrier protein reductase FabI, reducing bacterial burden in mice and rescuing mice from lethal infections with clinical isolates of Acinetobacter baumannii, Klebsiella pneumoniae and E. coli