AMX-883 a selective and orally active BRD9 molecular glue degrader that drives differentiation in acute myeloid leukaemia. AMX-883 shows selectivity over all other bromodomain containing proteins and proteome wide. AMX-883 does not employ the commonly used E3 ligases (cereblon, VHL) but instead drives degradation via DCAF16 as a targeted glue. AMX-883 can be used for the study of acute myeloid leukaemia (AML).

MRT-55811 is a first-in-class, highly selective CCNE1-targeting molecular glue degrader that achieves selective targeting of a previously undruggable target.

TNG961 functions as an orally available, selective molecular glue degrader that targets HBS1L. It is intended for the treatment of tumors characterized by FOCAD deficiency.

MRT-8102 is a molecular glue degrader that targets the NEK7 protein for the treatment of NLRP3 inflammasome-mediated inflammatory diseases.

NST-628 is a brain-penetrant molecular glue targeting the MAPK pathway, effectively inhibiting RAF phosphorylation and MEK activation. By binding to RAF, it disrupts the formation of BRAF-CRAF and BRAF-ARAF heterodimers, thereby blocking the RAS-MAPK signaling cascade. NST-628 exhibits potent anti-tumor activity in RAS- and RAF-driven cancers, demonstrating significant efficacy in mutant KRAS, NRAS, BRAF class II/III, and NF1-mutant tumor models.

NEO-811 is a molecular glue degrader specifically directed against ARNT (also known as HIF-1β). It demonstrates potent antitumor activity as a monotherapy in clear cell renal cell carcinoma (ccRCC).

TRI-611 is a highly potent and selective molecular glue degrader targeting ALK, with the ability to cross the blood-brain barrier. It is designed for the treatment of non-small cell lung cancer that tests positive for ALK fusion proteins.

TGFβRI-IN-2 (compound 18) is a potent, selective and orally active (Activin-Like Kinase 5) ALK 5 inhibitor with pIC50 and pEC50 values of 7.6 and 6.63, respectively. TGFβRI-IN-2 can produce observed cardiac toxicity in vivo at high dose.

MGD-22, a molecular glue, is an orally active IKZF1/2/3 degrader with DC50 values of 8.33 nM, 9.91 nM, and 5.74 nM, respectively. MGD-22 exhibits extremely potent anti-proliferative activity against diverse hematological cancer cells. MGD-22 induces apoptosis in cancer cells. MGD-22 demonstrates potent anti-tumor efficacy in mice bearing NCI-H929 xenografts or WSU-DLCL-2 xenografts. MGD-22 can be used for the study of hematological cancers, including multiple myeloma (MM), acute myeloid leukemia (AML), and diffuse large B-cell lymphoma (DLBCL).

SelDeg51 (Selective Degrader of FKBP51) is a potent, selective FKBP51 PROTAC with Kd of 18 nM, Emax=90%.

GSK147 (GSK-147) is an antimalarial compound that targets blood-stage activity of the Plasmodium falciparum and Plasmodium vivax parasites (Pf IC50=40 nM).

DS43260857 is a potent, selective NaV1.7 inhibitor with IC50 of 15 nM (hNaV1.7), shows 440-fold and 930-fold selectivity over hNaV1.1 and hNaV1.5, respectively.

Novel RORγt inhibitor, suppressing Th17 cell differentiation, reducing the severity of experimental autoimmune disease models such as EAU, EAE, and type 1 diabetes

Novel RORγt inhibitor, suppressing Th17 cell differentiation, reducing the severity of experimental autoimmune disease models such as EAU, EAE, and type 1 diabetes

EC18 HCN inhibitor is a HCN channel inhibitor. EC18 acts as a potent HCN4 inhibitor in a human iPSC-derived sinus node model with proven HCN4 expression. EC18 is an attractive pharmacological tool, enabling HCN channel-modulation studies with some specificity for HCN4 (EC50 [HCN4] = 3.98 ± 1.16 µM) over HCN1 (EC50 = 21.00 ± 3.98 µM) and HCN2 (EC50 = 19.35 ± 4.48 µM). EC18 abolishes HCN4 triggered pace making in a human iPSC (hiPSC) pacemaker model.

Imidacloprid is an effective and widely used neonicotinoid pesticide to control pests of cereals, vegetables, tea and cotton.

Methylergonovine Maleate is the maleate salt of methylergonovine, a semi-synthetic ergot alkaloid with vasoconstrictive and uterotonic effects. Methylergonovine stimulates serotoninergic and dopaminergic receptors as well as inhibits the release of endothelial-derived relaxation factor. This results in arterial vasoconstriction and increased uterine smooth muscle contractions.

a KRASG12D degrader for the treatment of solid tumors.

Acetylglucosamine or N-acetylglucosamine is potentially for the treatment of irritable bowel syndrome. N-Acetylglucosamine (GlcNAc) is a monosaccharide that usually polymerizes linearly through (1,4)-β-linkages. GlcNAc is the monomeric unit of the polymer chitin, the second most abundant carbohydrate after cellulose. In addition to serving as a component of this homogeneous polysaccharide, GlcNAc is also a basic component of hyaluronic acid and keratin sulfate on the cell surface. GlcNAc has been reported to be an inhibitor of elastase release from human polymorphonuclear leukocytes (range 8–17% inhibition), however this is much weaker than the inhibition seen with N-acetylgalactosamine (range 92–100%).

Upacicalcet (sodium) is an intravenous calcimimetic agent. Upacicalcet suppresses excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels, by acting directly on parathyroid cell membrane calcium-sensing receptors. Upacicalcet can be used for researching the disease of secondary hyperparathyroidism (SHPT).

Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. This is the first drug that was specifically approved to help with mobility in these patients. It has been approved by the FDA for use as a treatment for multiple sclerosis.

Menbutone is an oxobutyric acid derivative and acts as a choleretic.

Levomenol ((-)-α-Bisabolol), a monocyclic sesquiterpene alcohol, exerts antioxidant, anti-inflammatory, and anti-apoptotic activities. Levomenol also has neuroprotective effects and prevents neuronal damage and memory deficits through reduction of proinflammatory markers induced by permanent focal cerebral ischemia in mice. Levomenol attenuates nociceptive behaviour and central sensitisation in a rodent model of trigeminal neuropathic pain. Orally active.

Squalane is used as a lubricant for fatty acid surfactant films adsorbed on iron oxide surfaces

Amikacin is an aminoglycoside antibiotic derived from kanamycin A. Like other aminoglycosides, amikacin binds to bacterial ribosomes and disrupts translation.1 However, the specific binding sites differ between different aminoglycoside antibiotics, as do the mechanisms of resistance. Amikacin is effective against Gram-negative and Gram-positive bacteria.

Squalene is a biosynthetic precursor to all steroids. An oil-in-water emulsion of squalene synergistically increases adaptive immune responses to glucopyranosyl lipid adjuvant (GLA), a toll-like receptor 4 (TLR4) agonist, compared with an aqueous formulation of GLA. Formulations containing squalene have been used as adjuvants in vaccines and as hair and skin conditioning agents.

Heptanoic acid, also called enanthic acid, is an organic compound composed of a seven-carbon chain terminating in a carboxylic acid. It is an oily liquid with an unpleasant, rancid odor. It contributes to the odor of some rancid oils.

Butylated hydroxytoluene is di-tert-butyl PHENOL with antioxidant properties.

Diethyl adipate has an antifertility effects.