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PROTACs

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Cat. No. Product Name Field of Application Chemical Structure
DC22207 AP1903 Featured
AP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM.
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DC67803 Thalidomide-NH-C10-COOH Featured
Thalidomide-NH-C10-COOH (compound 6b) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based CRBN ligand and a linker used in PROTAC technology.
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DC50065 (S,R,S)-AHPC-CO-CI-Br Featured
(S,R,S)-AHPC-CO-CI-Br is a novel protac building block,
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DC67802 Pomalidomide-PEG4-C2-NH2 hydrochloride Featured
Pomalidomide-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in the synthesis of PROTACs.
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DC11569 E3 Ligand-Linker Conjugate 4 Featured
E3 Ligand-Linker Conjugate 4 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTAC, such as MDM2 PROTAC degrader.
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DC36456 DMPAC-Chol Featured
DMPAC-Chol is a cationic cholesterol derivative that has been used in liposome formation for gene transfection. Liposomes containing DMPAC-chol bind to DNA in a band shift assay and protect against serum nuclease degradation of DNA.
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DC67801 6-amino-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hexanamide Featured
DC67800 5-[(4-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, Featured
DC67799 Thalidomide-5-NH-PEG1-NH2 hydrochloride Featured
Thalidomide-5-NH-PEG1-NH2 hydrochloride is a Thalidomide (HY-14658)-based cereblon ligand that recruits CRBN proteins.
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DC67798 5-[(6-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, Featured
DC34571 TL12-186
TL12-186 is a multikinase degrading PROTAC.
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DC67797 5-((14-amino-3,6,9,12-tetraoxatetradecyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Featured
DC67796 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-triMethyl-, (6R)- Featured
DC26169 MS1943 Featured
MS1943 is a first-in-class, orally bioavailable EZH2 selective degrader, with an IC50 of 120 nM. MS1943 significantly reduces EZH2 protein levels in numerous triple-negative breast cancer (TNBC) and other cancer and noncancerous cell lines.
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DC67795 INDEX NAME NOT YET ASSIGNED Featured
DC67794 Thalidomide-O-PEG4-NHS ester Featured
Thalidomide-O-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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DC67793 Thalidomide-O-amido-C6-NH2 hydrochloride Featured
Thalidomide-O-amido-C6-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.
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DC45727 Thalidomide-O-C5-NH2 hydrochloride Featured
Thalidomide-O-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
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DC8261 (-)-JQ-1 Featured
The (-)-JQ1 stereoisomer has no appreciable affinity to BET bromodomains,it is the negative control of +JQ-1.
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DC5019 (+)-JQ1 Featured
(+)-JQ1 is a BET bromodomain inhibitor, binding to all bromodomains of the BET family, but not to bromodomains outside the BET family.
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DC67792 Benzonitrile, 4-(4-methyl-5-thiazolyl)-2-(phenylmethoxy)- Featured
DC67791 5-(Benzyloxy)pyridine-2-carboxylic Acid Featured
DC67790 Benzoic acid, 4-chloro-3-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)- Featured
DC67787 4-BROMO PHTHALIC ANHYDRUS Featured
DC67786 Benzoic acid, 2-(6-azaspiro[2.5]oct-6-yl)-4-iodo- Featured
DC67784 N-Boc-O-tosyl hydroxylamine Featured
N-Boc-O-tosyl hydroxylamine is used as a safe and efficient nitrogen source for the N-amination of aryl and alkyl amines.
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DC67783 CRBN ligand-225 Featured
CRBN ligand-225 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein.
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DC67782 Biotin NHS Featured
Biotin NHS is an amino reactive biotin reagent used in the preparation of biotinylated surfaces or polypeptides.
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DC67781 CRBN ligand-224 Featured
CRBN ligand-224 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-224 can be linked to a target protein ligand via a linker to form a PROTAC.
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DC67780 Thalidomide acid Featured
Thalidomide acid is a Thalidomide analog that can be useful in PROTAC research.
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