A12-Iso5-2DC18|LNP|DC Chemicals

Cas No.:	2412492-06-7
Chemical Name:	A12-Iso5-2DC18
Synonyms:	1H -Imidazole-2-carboxylic acid, 1-[3-(dimethylamino)propyl]-5,5-di- (8Z )-8-heptadecen-1-yl-2,5-dihydro-, ethyl ester (ACI);A12Iso52DC18， A12 Iso5 2DC18
SMILES:	C(CCCCCC/C=C\CCCCCCCC)C1(CCCCCCC/C=C\CCCCCCCC)N(CCCN(C)C)C(C(OCC)=O)N=C1
Formula:	C₄₅H₈₅N₃O₂
M.Wt:	700.18
Purity:	ELSD-HPLC>95%
Sotrage:	1 year -20°C
Publication:	Synthesis of ionizable lipidoids for pharmaceutical use By: Miao, Lei; Li, Linxian; Anderson, Daniel Griffith; Huang, Yuxuan World Intellectual Property Organization, WO2020047399 A1 2020-03-05.

Cat. No.	Product name	Field of application
DC60821	Lipid TOT-5	TOT-5, a tri-oleoyl-Tris ionizable lipid (pKa 6.2), enables splenic B cell-targeted mRNA delivery via 15% DSPC-incorporated LNPs. Its charge-neutral, hydrophobic surface minimizes hepatic ApoE uptake and enhances complement C3 adsorption, facilitating CD21/35-mediated uptake by marginal zone B cells. In vivo, intravenous 15%DSPC-LNPs showed 8-fold higher spleen-to-liver luciferase expression vs 3%DSPC, with anti-CD21/35 blocking 60% B cell uptake. Intramuscular administration induced robust OVA-specific IgG (10^5 titer) and CTL responses (3.5% tetramer+ CD8+ T cells) while reducing hepatotoxicity (ALT/AST levels ≤40 U/L vs SM-102-LNPs' 80-120 U/L). Cryo-ET confirmed stable lamellar structures (80-100 nm, ζ-potential -2 mV). This formulation achieves safe, ligand-free splenic targeting for mRNA vaccines.
DC66219	Lipid 88	Lipid88 is a high-performance, novel ionizable lipid component engineered for advanced mRNA-LNP vaccine delivery. LNP88 formulation demonstrates superior biodistribution, achieving >10-fold higher transfection efficiency in spleen and lymph nodes compared to benchmark lipids like ALC-0315 via intramuscular delivery. When encapsulating antigen-encoding mRNA (e.g., optimized mCSA construct), Lipid-88 based LNPs drive robust humoral and cellular immunity, enabling complete protection against challenging SARS-CoV-2 variants (WA1/2020, Omicron BA.1, BQ.1) in preclinical models. Its design prioritizes potent immunogenicity with favorable safety profiles.
DC65329	ALC-0315 analogue-2	ALC-0315 analogue-2 is an analogue of ALC-0315. ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine.
DC82003	A12-Iso5-2DC18	A12-Iso5-2DC18 is a novel amine containing lipid can be used for mRNA delivery, activate the stimulator of interferon genes (STING) pathway, and exhibit anti-tumor immunity.
DC80071	A18-Iso5-2DC18	A18-Iso5-2DC18 that could not only deliver mRNA vaccines robustly but also activate the stimulator of interferon genes (STING) pathway.