ML-T531| CAS 791127-70-3|DC Chemicals

Cas No.:	791127-70-3
Chemical Name:	2-(4-Benzoylphenoxy)-N-pyridin-3-ylacetamide
Synonyms:	MLS001179913;2-(4-benzoylphenoxy)-N-pyridin-3-ylacetamide;SMR000595433;BDBM97142;cid_2534340;HMS2904N24;2-(4-benzoylphenoxy)-N-(3-pyridyl)acetamide;2-(4-benzoylphenoxy)-N-(3-pyridinyl)acetamide;2-(4-benzoylphenoxy)-N-(pyridin-3-yl)acetamide;Z31790281;2-[4-(phenylcarbonyl)phenoxy]-N-pyridin-3-yl-ethanamide
SMILES:	O(CC(NC1C=NC=CC=1)=O)C1C=CC(=CC=1)C(C1C=CC=CC=1)=O
Formula:	C₂₀H₁₆N₂O₃
M.Wt:	332.352644920349
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	References 1. Zhang H, et al. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11866-71. 2. Yu Z, et al. Eur J Med Chem. 2015 Dec 1;106:50-9. 3. Yu Z, et al. Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e003439. View Related Products by Target Potassium Channel

Description:

ML-T531 is a potent, selective hERG potassium channel (Kv11.1) activator with EC50 of 3.13 uM; exhibits no potentiation for KCNQ1 and KCNE1, and no noticeable effects on other cardiac channels including Cav1.2, Kir2.1, Nav1.5, and Kv4.3; significantly potentiates hERG steady-state currents and tail currents in CHO cells at 10 uM, enhances voltage-dependent potassium current amplitudes in the presence of an Iks-specific inhibitor chromanol 293B; potentiates native potassium currents in iPSC-derived cardiomyocytes, shortens the APD90 of LQT1 cardiomyocytes with EC50 of 5.71 uM, normalizes the disease phenotype of cardiomycytes derived from a patient with LQT1.

References:

References 1. Zhang H, et al. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11866-71. 2. Yu Z, et al. Eur J Med Chem. 2015 Dec 1;106:50-9. 3. Yu Z, et al. Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e003439. View Related Products by Target Potassium Channel

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