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VHN22300

  Cat. No.:  DC67730   Featured
Chemical Structure
2374122-30-0
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More than 5000 active chemicals with high quality for research!
Field of application
VHN22300, also known as (S,R,S)-AHPC-PEG3-Alkyne, is a ProTAC building block. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate ProTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Cas No.: 2374122-30-0
Chemical Name: VHN22300
Synonyms: (2S,4R)-1-[(2S)-3,3-Dimethyl-2-[3-[2-(2-prop-2-ynoxyethoxy)ethoxy]propanoylamino]butanoyl]-4-hydroxy;(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(S,R,S)-AHPC-PEG3-Alkyne;(S,R,S)-AHPC-CO-PEG3-propargyl;G86352;VHL032-amido-PEG3-C-Alkyne;(S,R,S)-AHPC-PEG3-Alkyne
SMILES: S1C=NC(C)=C1C1C=CC(=CC=1)CNC([C@@H]1C[C@H](CN1C([C@H](C(C)(C)C)NC(CCOCCOCCOCC#C)=O)=O)O)=O
Formula: C32H44N4O7S
M.Wt: 628.779367446899
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Cat. No. Product name Field of application
DC67762 CRBN ligand-204 CRBN ligand-204 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-204 can be linked to a target protein ligand via a linker to form a PROTAC.
DC67752 5-Amino-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]pentanamide
DC67751 tert-butyl 3-({3-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]prop-2-yn-1-yl}oxy)propanoate
DC67750 Desamino lenalidomide-5-acetonitrile Desamino lenalidomide-5-acetonitrile is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-5-acetonitrile can be linked to a target protein ligand via a linker to form a PROTAC.
DC67749 Pomalidomide-C2-acid Pomalidomide-C2-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
DC67748 Pomalidomide 4'-alkylC3-acid Pomalidomide 4'-alkylC3-acid is the E3 ligase ligand-linker conjugate used in the recruitment of CRBN protein. Pomalidomide 4'-alkylC3-acid can be used to synthesize PROTACs.
DC67747 2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-4-(2-propyn-1-yloxy)-2H-isoindol-2-yl]-
DC67746 E3 ligase Ligand 63 E3 ligase Ligand 63 is an E3 ligase ligand that can be used to synthesize CDK2 degrader 2 (HY-163815).
DC67745 (S,R,S)-AHPC--CO-PEG1-C2-amine HCl
DC67744 Thalidomide-O-amido-C4-NH2 hydrochloride Thalidomide-O-amido-C4-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.
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