HOIPIN-1 (JTP-0819958, HOIP inhibitor-1) is a chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=2.8 uM), specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the N

UCF-101 is a selective inhibitor of the pro-apoptotic mitochondrial serine protease Omi/HtrA2 involved in the cellular response to thermal and oxidative stress.

Novel mucolipin 1 (ML1) agonist, inducing lysosomal Ca2+ release, ameliorating muscular dystrophies and activating TFEB to correct lysosomal insufficiency in mdx mice

JR-AB2-011 is a potent and selective inhibitor of mTORC2 kinase activity. It markedly reduces mTORC2 signaling and IC50 while enhancing apoptotic levels in GBM cells.

NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo.

DB818 (DB-818, DB 818) is a small molecule inhibitor of HOXA9/DNA interaction through binding as minor groove DNA ligand on the HOXA9 cognate sequence.

SR31527 is a novel allosteric Kinesin-like protein KIFC1 inhibitor that inhibits microtubule-stimulated KIFC1 ATPase activity with IC50 of 6.6 uM, binds directly to KIFC1 with Kd of 25.4 nM.

NPD8733 (NPD-8733) is a small-molecule ligand of valosin-containing protein (VCP)/p97, binds to the D1 domain of VCP/p97.

SC-57461A is a highly potent, orally bioavailable nonpeptide compound that selectively inhibits Leukotriene A4 (LTA4) hydrolase. It demonstrates strong activity with IC50 values of 2.5 nM (human), 3 nM (mouse), and 23 nM (rat) for recombinant LTA4 hydrolase.

VPC-80051 (VPC80051) is the first small molecule inhibitor of hnRNP A1 splicing activity, targets RNA-binding domain (RBD) of hnRNP A1.

RG7834 (RO 7020322) is a highly selective and orally bioavailable HBV inhibitor, potently inhibits HBV antigens (both HBsAg and HBeAg) and HBV DNA, with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells.

A-485 is a highly potent and selective small-molecule inhibitor targeting the catalytic activity of p300/CBP histone acetyltransferases (HATs). It demonstrates remarkable inhibitory potency, with IC50 values of 9.8 nM (p300) and 2.6 nM (CBP).

CVT-11127 functions as a potent inhibitor of stearoyl-CoA desaturase (SCD), demonstrating significant biological activity. This compound triggers apoptotic pathways and effectively halts cell cycle progression at the G1/S transition phase. Due to these mechanisms of action, CVT-11127 shows promise as a candidate for lung cancer research.

NS13001 is a highly selective and orally bioavailable allosteric positive modulator targeting small-conductance calcium-activated potassium (SK) channels. It exhibits potent activity, with EC50 values of 1.8 μM for SK2 and 0.14 μM for SK3, demonstrating greater potency toward SK3. Due to its pharmacological profile, NS13001 has emerged as a promising candidate for treating spinocerebellar ataxia type 2 (SCA2) and may also have therapeutic potential in other forms of cerebellar ataxia.

GNE-140 racemate consists of equal parts (R)-GNE-140 and (S)-GNE-140 enantiomers, functioning as a potent inhibitor of lactate dehydrogenase A (LDHA).

AA 41612 is a potent, synthetic melanopsin antagonist with IC50 of 15.8 nM, attenuates melanopsin photocurrent in a dose-dependent manner.

KLH45 is a selective inhibitor of DDHD2 (DDHD domain containing 2).

WWL229 is a selective, distinct Carboxylesterase Ces3 inhibitor with IC50 of 1.94 uM, but not Ces1f, ABHD6, other serine hydrolases.

NCGC00262650 demonstrates potent inhibition of the AMA1-RON2 protein interaction, effectively preventing merozoite invasion of erythrocytes.

ML-226 is an inhibitor of α/β hydrolase domain-containing protein 11 (ABHD11) that inhibits ABHD11 in vitro and in situ.

BMS-986188 functions as a selective positive allosteric modulator for the δ-opioid receptor, demonstrating potent activity with an EC50 of 50 nM.

NCGC607 is a a small-molecule noninhibitory chaperone of glucocerebrosidase.

Metarrestin (ML246) is a specific inhibitor of perinuclear compartment (PNC), disrupts PNCs in PC3M-GFP-PTB cells with IC50 of 0.39 uM, specifically binds eEF1A2.

NSC45586 sodium is a selective inhibitor targeting the PP2C phosphatase domain within both PHLPP1 and PHLPP2 proteins. By blocking these phosphatases, it enhances AKT activation in neuronal cells.

FLTX1 is a fluorescent Tamoxifen analog capable of specifically visualizing intracellular estrogen receptor binding sites, regardless of cellular permeabilization status. This probe retains Tamoxifen's potent antiestrogenic activity in breast cancer models while lacking uterine estrogenic effects.

Negative control for GSK'963 (AOB9775). Novel highly potent and selective RIP1 inhibitor

TSPC is an inhibitor for GA perception by in vitro and in planta evaluations.

ML311 is a potent and selective inhibitor of the Mcl-1/Bim interaction.

MSBN is a highly selective fluorogenic probe for thiols, selectively imaging thiols in live cells and specifically label protein thiols with a turn-on signal to determine diverse reversible protein thiol modifications.

BRD6688 is a selective HDAC2 inhibitor. It acts by enhancing the learning and memory processes.