Novel Sirtuin1 Activator, Down-Regulating Sclerostin and Rescuing Ovariectomy-Induced Bone Loss

Novel MOR agonist/DOR antagonist that produced systemically active potent antinociceptive activity in tail-flick assay in mice

Novel GLUT inhibitor, preferentially inhibiting the growth of GBM cells with minimal toxicity to non-neoplastic astrocytes and neurons, also inhibiting glucose uptake and decrease the glycolytic capacity and glycolytic reserve capacity of GBM patient-deri

Novel GLUT inhibitor, preferentially inhibiting the growth of GBM cells with minimal toxicity to non-neoplastic astrocytes and neurons, also inhibiting glucose uptake and decrease the glycolytic capacity and glycolytic reserve capacity of GBM patient-deri

Novel potent inhibitor of Wn/ß-catenin signaling in cancer cells

Novel inhibitor of thrombospondin 1 activation of TGF-β, blocking TGF-β activation (pIC50 = 8.12 nM) and has a plasma half life of 1.8 h (iv)

Potent DAT allosteric modulator, partially inhibiting DAT uptake without altering DAT-mediated reverse transport and with minimal inhibition of DAT binding

Highly blood-brain barrier permeant, potent, and selective for LRRK2 kinase activity, being effective in attenuating pro-inflammatory responses in macrophages and rescuing neurite retraction phenotypes in neurons.

Novel mixed μ opioid receptor (MOR) agonist and δ/κ opioid receptor (DOR/KOR) antagonist

Novel inhibitor of sterol regulatory element-binding protein (SREBP), impairing the SREBP activity by inhibiting glucose transporters and thereby activating AMP-activated protein kinase (AMPK)

Peptide substrate for many protein kinases, such as Blk, BTK, cKit, EPHA1, EPHB2, EPHB3, ERBB4, FAK, Flt3, IGF-1R, ITK, Lck, MET, MUSK, Ret, Src, TIE2, TrkB, VEGF-R1 (Flt-1) and VEGF-R2 (KDR)

Novel Selective TBK1/IKK dual inhibitor with anticancer potency

The first selective β3 adrenergic agonist, showing to possess a profile of antidepressant activity in rodents

Novel renin inhibitor

Novel Inhibitor of c-Jun N-terminal Kinase 3 (JNK3)

Potent inhibitor of both JNK3 and p38

Novel NR4A nuclear receptor modulator

Novel partial agonist of PPARgamma

Novel Unc-51-Like Kinase 1 (ULK1)

Selective neurotensin antagonist

Novel NR4A nuclear receptor modulator

Novel NR4A nuclear receptor modulator

Novel inhibitor of the in vivo aggregation of

Novel specific PAK4 inhibitor, effectively inhibiting the invasion of SGC7901 cells without cytotoxicity, regulating the PAK4/LIMK1/cofilin and PAK4/SCG10 signaling pathways

Novel potent and selective binder of small subunit B of the serine palmitoyltransferase complex (SPTSSB)

Novel potent serine palmitoyl transferase (SPT) inhibitor

Novel SPOP inhibitor, suppressing the viability and inhibiting the colony formation of ccRCC cell lines driven by cytoplasmic SPOP

Pivotal intercellular signal transmitter

USP7 inhibitor from the marine sponge Stylissa massa

Novel isosteric charge-deficient spermine analogue