BEC hydrochloride|CAS 222638-67-7|DC Chemicals

Cas No.:	222638-67-7
Chemical Name:	BEC HCl
Synonyms:	L-Cysteine,S-(2-boronoethyl)-, hydrochloride (1:1);L-Cysteine,S-(2-boronoethyl)-, hydrochloride (9CI);BEC HCl;(R)-2-amino-3-((2-boronoethyl)thio)propanoic acid hydrochloride;BEC (hydrochloride);S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE;BEC hydrochloride;(2R)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid hydrochloride;bec-hydrochloride;BCP25043;S-(2-Boronoethyl)-l-cysteine, HCl;(R)-2-Amino-3-(2-boronoethylthio)propanoic acid hydrochloride;(2R)-2-amino-3-{[2-(dihydroxyboranyl)ethyl]sulfanyl}propanoic acid hydrochloride
SMILES:	Cl[H].S(C([H])([H])C([H])([H])B(O[H])O[H])C([H])([H])[C@@]([H])(C(=O)O[H])N([H])[H]
Formula:	C₅H₁₃BClNO₄S
M.Wt:	229.482
Sotrage:	4°C for 1 year, -20°C for more than 2 years

Description:

BEC HCl is a slow-binding and competitive Arginase II inhibitor with Ki of 0.31 μM (ph 7.5).

In Vitro:

BEC HCl causes significant enhancement of NO-dependent smooth muscle relaxation in this tissue. [2] BEC HCl enhances perivascular and peribronchiolar lung inflammation, mucus metaplasia, NF-κB DNA binding, and mRNA expression of the NF-κB-driven chemokine genes CCL20 and KC, and lead to further increases in airways hyperresponsiveness. [3] In vivo: BEC HCl increased contractility in isolated myocytes from WT and NOS3 but not NOS1 knockout mice. [4]

Cat. No.	Product name	Field of application
DC9964	BEC hydrochloride	BEC is a boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginase I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5).