BTT-266 |CAS 2413939-89-4|DC Chemicals

Cas No.:	2413939-89-4
Chemical Name:	INNYA-22110402
SMILES:	C1(C2CC(C3C(C4C=CC(C)=CC=4)=NN(C4C=CC=CC=4)C=3)N(N=2)C(=O)C2=CC(=CC=C2)C(=O)O)C=CC(=CC=1)OC
Formula:	C₃₄H₂₈N₄O₄
M.Wt:	556.61
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

BTT-266 (BTT266) is a voltage-gated CaV2.2 calcium channel inhibitor that disrupts the CaVα·CaVβ3 protein-protein interaction, directly binds to CaVβ3 with Kd of 3.6 uM; decreases surface presentation of the CaV2.2α1 subunit, significantly reduces trafficking of CaV2.2 to the plasma membrane at 50 uM, does not affect CaV2.2 currents in either in HEK-CaV2.2 cells or rat dorsal root ganglion (DRG) neurons.

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