CLP290|CLP-290|CAS 1181083-81-7|DC Chemicals

Cas No.:	1181083-81-7
Chemical Name:	[5-Fluoro-2-[(Z)-(2-hexahydropyridazin-1-yl-4-oxo-thiazol-5-ylidene)methyl]phenyl] pyrrolidine-1-carboxylate
Synonyms:	CLP-290,CLP 290,CLP290
SMILES:	N(C(OC1=CC(F)=CC=C1/C=C1\SC(N2NCCCC2)=NC\1=O)=O)1CCCC1
Formula:	C₁₉H₂₁FN₄O₃S
M.Wt:	404.46
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Chen B, et al. Cell. 2018 Jul 26;174(3):521-535.e13. 2. Ferrini F, et al. Sci Rep. 2017 Jun 20;7(1):3870.

Description:	CLP290 is an orally available activator of the neuron-specific K+-Cl− cotransporter KCC2, displays potential for treatment of a wide range of neurological and psychiatric indications. CLP290 can significantly lower blood arginine-vasopressin (AVP) and glucose levels in STZ rats[1][2].
Target:	KCC2[1]
References:	[1]. Ferrini F, et al. Enhancing KCC2 function counteracts morphine-induced hyperalgesia. Sci Rep. 2017 Jun 20;7(1):3870. [2]. Gagnon M, et al. Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat Med. 2013 Nov;19(11):1524-8. [3]. Kim YB, et al. Excitatory GABAergic Action and Increased Vasopressin Synthesis in Hypothalamic Magnocellular Neurosecretory Cells Underlie the High Plasma Level of Vasopressin in Diabetic Rats. Diabetes. 2018 Mar;67(3):486-495.

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