DS-70|α4 integrin inhibitor DS-70

Cas No.:
Chemical Name:	(S)-(1-(2-(4-(3-(o-tolyl)ureido)phenyl)acetyl)pyrrolidine-3-carbonyl)glycine
Synonyms:	α4 integrin inhibitor DS-70
SMILES:	C(O)(=O)CNC([C@@H]1CCN(C(CC2=CC=C(NC(NC3=CC=CC=C3C)=O)C=C2)=O)C1)=O
Formula:	C₂₃H₂₆N₄O₅
M.Wt:	438.484
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

DS-70 (α4 integrin inhibitor DS-70) is a novel potent α/β- peptidomimetic antagonist of α4 integrin, binds to integrin α4β1 with nanomolar affinity; prevents the adhesion of α4 integrin-expressing cells, antagonizes VCAM-1-mediated degranulation of mast cells and eosinophils and ERK 1/2 phosphorylation; does not inhibit cell adhesion mediated by the leukocyte integrins aLb2 and aMb2 or by the Arg-GlyAsp (RGD)-binding integrins α5β1, αVβ3, αVβ5, αVβ6 and αIIbβ3; dose-dependently reduces the clinical symptoms of allergic conjunctivitis, conjunctival α4 integrin expression and conjunctival levels of chemokines and cytokines in ovalbumin-sensitized guinea pigs.

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