Olomoucine|cas 101622-51-9|DC Chemicals

Cas No.:	101622-51-9
Chemical Name:	Ethanol,2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-
Synonyms:	Ethanol,2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-;Olomoucine;2-[[6-(benzylamino)-9-methylpurin-2-yl]amino]ethanol;OLO;Olomoucine,high purity;2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine;6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine;NSC 666096;OLOMOUCINE;Olomoucine,highpurity;OLOMOUCINE SYNTHETIC >95%;Olomoucine,98%,high purity;N2-[(2-HYDROXYETHYL)]-N6-BENZYLADENINE;2-(hydroxyethylamino)-6-benzylamino-9-methylpurine;6-BENYLAMINO-2-(2-HYDROXYETHYLAMINO)-9-METHYLPURINE;6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-9-METHYLPURINE;2-(2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-METHYLPURINE
SMILES:	CN1C=NC2C1=NC(NCCO)=NC=2NCC1C=CC=CC=1
Formula:	C₁₅H₁₈N₆O
M.Wt:	298.343021869659
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Olomoucine is an ATP competitive inhibitor of CDKs. Olomoucine is a purine (HY-34431) derivative and inhibits CDC2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E (both IC50=7 µM), CDK/p35 kinase (IC50=3 µM) and ERK1/p44 MAP kinase (IC50=25 µM)[1][2].
Target:	cdk2-cyclin A:7 μM (IC50) cdk2-cyclin E:7 μM (IC50)
References:	[1]. Vesely, J., Havlicek, J., Strnad, M., et al. Inhibition of cyclin-dependent kinases by purine analogues. European Journal of Biochemistry 224, 771-786 (1994). [2]. 2.Abraham, R.T., Acquarone, M., Andersen, A., et al. Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biology of the Cell 83(2), 105-120 (1995).

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