PKC-IN-6c|CAS 2026603-86-9|DC Chemicals

Cas No.:	2026603-86-9
Chemical Name:	3,3-bis(4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-2-phenylacrylonitrile
Synonyms:	PKC inhibitor 6c
SMILES:	C(#N)/C(/C1=CC=CC=C1)=C(/C1=CC=C(OCCN2CCN(C)CC2)C=C1)\C1=CC=C(OCCN2CCN(C)CC2)C=C1
Formula:	C₃₅H₄₃N₅O₂
M.Wt:	565.762
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A novel, potent, brain permeant PKC inhibitor with IC50 of 80 nM, without detectable binding to the estrogen receptor (Ki>10 uM); effectively blocks amphetamine-induced locomotor stimulation, more potently inhibits PKC than tamoxifen and reduces amphetamine-stimulated dopamine efflux.

Cat. No.	Product name	Field of application
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DC50087	1,2-Dimyristoyl-sn-glycerol	1,2-Dimyristoyl-sn-glycerol is a saturated diacylglycerol and a weak second messenger for the activation of PKC.
DC46451	CC-90005	CC-90005 is a potent, selective and orally active inhibitor of protein kinase C-θ (PKC-θ), with an IC50 of 8 nM. CC-90005 shows selectivity for PKC-θ over PKC-δ (IC50=4440 nM). CC-90005 can inhibit T cell activation by IL-2 expression.
DC40357	PKC-iota inhibitor 1	PKC-iota inhibitor 1 (compound 19) is a protein kinase C-iota (PKC-ι ?) inhibitor with an IC50 value of 0.34 μM.
DC40325	ζ-Stat trisodium	ζ-Stat trisodium (NSC37044 trisodium) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat trisodium can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro.
DC28545	N-Desmethyltamoxifen hydrochloride	N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent re
DC28544	N-Desmethyltamoxifen	N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.
DC28223	Bisindolylmaleimide IV	Bisindolylmaleimide IV (Arcyriarubin A) is a potent protein kinase C (PKC) inhibitor, with IC50s ranging from 0.1 to 0.55 μM. Bisindolylmaleimide IV also inhibits PKA (IC50=3.1-11.8μM). Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with an IC50 of 0.2 μM.
DC7382	CGP60474	CGP60474 is a potent inhibitor of cyclin-dependent kinase (CDK).
DC7421	GO 6976	Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.