NEDD8 inhibitor M22|cas 864420-54-2|DC Chemicals

Cas No.:	864420-54-2
Chemical Name:	NAE-IN-M22
Synonyms:	1-benzyl-N-[2-(2,4-dichlorophenyl)ethyl]piperidin-4-amine;NEDD8 inhibitor M22;NAE-IN-M22
SMILES:	ClC1C=C(C=CC=1CCNC1CCN(CC2C=CC=CC=2)CC1)Cl
Formula:	C₂₀H₂₄Cl₂N₂
M.Wt:	363.323963165283
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	NEDD8 inhibitor M22 is a novel, potent, selective reversible NEDD8 activating enzyme (NAE) inhibitor; inhibit A549 cell proliferation completely at 30 uM (GI50=5.5 uM and GI90=19.3 uM); produces tumor inhibition in AGS xenografts in nude mice and low acute toxicity in zebrafish model; exhibts different binding mode compared with MLN4924.
References:	References 1. Lu P, et al. ACS Chem Biol. 2016 Jul 15;11(7):1901-7. View Related Products by Target Ubiquitin-activating Enzyme (E1)

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