RAD51-IN-17|cas 2101739-18-6|DC Chemicals

Cas No.:	2101739-18-6
Chemical Name:	RAD51-IN-1
Synonyms:	(E)-3-(4-Chlorobenzyl)-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one;RAD51-IN-1
SMILES:	ClC1C=CC(=CC=1)CN1C(C2C=CC=CC=2N=C1/C=C/C1C=NC=CC=1)=O
Formula:	C₂₂H₁₆ClN₃O
M.Wt:	373.840
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

AFN39186(RAD51-IN-17) is a quinazolinone derivative that inhibts homologous recombinase RAD51, effectively inhibits both RAD51 foci formation in response to DNA damage, and proliferation of TNBC cell lines; also sensitizes aggressive metastatic TNBC to DNA damage induced by irradiation; a valuable research tool for developing combination therapies to overcome RAD51 driven resistance and relapse in a variety of cancers.

References:

References 1. Ward A, et al. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3096-3100. View Related Products by Target DNA Repair Protein

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