APX001|APX 001A;E1210|CAS 936339-60-5

Cas No.:	936339-60-5
Chemical Name:	3-(3-{4-[(pyridin-2-yloxy)methyl]benzyl}isoxazol-5-yl)pyridin-2-amine
Synonyms:	APX001,APX 001;E1210,E 1210,E 1210
SMILES:	NC1=NC=CC=C1C2=CC(CC3=CC=C(COC4=NC=CC=C4)C=C3)=NO2
Formula:	C₂₁H₁₈N₄O₂
M.Wt:	358.401
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

APX001 (APX 001A;E1210) is a novel broad-spectrum antifungal agent that inhibits the fungal protein Gwt1, demonstrates significantly acitive MIC50 and MIC90 values of 0.004 and 0.031 ug/ml (16 strains of C. auris); inhibits the inositol acylation activity of C. albicans Gwt1p and A. fumigatus Gwt1p with IC50 of 0.3 to 0.6 uM but has no inhibitory activity against human Pig-Wp; shows significant efficacy in murine model of disseminated C. auris infection, and log reduction in CFU counts in kidney, lung, and brain tissue. Fungal Infection Phase 1 Clinical

References:

References 1. Hager CL, et al. Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02319-17. 2. Zhao M, et al. Antimicrob Agents Chemother. 2018 Jan 29. pii: AAC.02542-17. 3. Watanabe NA, et al. Antimicrob Agents Chemother. 2012 Feb;56(2):960-71. 4. Miyazaki M, et al. Antimicrob Agents Chemother. 2011 Oct;55(10):4652-8. View Related Products by Target Fungal Fungal Infection

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APX001A