DS-7423|CAS 1222104-37-1|DC Chemicals

Cas No.:	1222104-37-1
Chemical Name:	DS-7423
Synonyms:	DS-7423
SMILES:	C1OCCN(C2=C3N=C(N4CCN([C@H](C)C4)C(C)=O)N(CC(F)(F)F)C3=NC(C3C=NC(N)=NC=3)=N2)C1
Formula:	C₂₂H₂₇F₃N₁₀O₂
M.Wt:	520.51
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

DS-7423 is a novel potent, small-molecule dual inhibitor of PI3K/mTOR with IC50 of 15.6, 1143, 249, 262 and 34.9 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR respectively; exerts anti-tumor effect against a panel of nine OCCA cell lines with IC50 of <75 nM, regardless of the mutational status of PIK3CA; suppresses the tumor growth of OCCA in a dose-dependent manner in mouse xenograft models.Solid TumorsPhase 1 Discontinued

References:

References 1. Koul D, et al. Oncotarget. 2017 Mar 28;8(13):21741-21753. 2. Kashiyama T, et al. PLoS One. 2014 Feb 4;9(2):e87220. View Related Products by Target PI3K Solid Tumors

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