KAR-5585|KAR5585;Rodatristat|DC Chemicals

Cas No.:	1673571-51-1
Chemical Name:	Rodatristat ethyl
Synonyms:	Rodatristat ethyl;KAR5585;507FY6OL37;Rodatristat ethyl (USAN);Rodatristat ethyl [USAN];2,8-Diazaspiro(4.5)decane-3-carboxylic acid, 8-(2-amino-6-((1R)-1-(5-chloro(1,1'-biphenyl)-2-yl)-2,2,2-trifluoroethoxy)-4-pyrimidinyl)-, ethyl ester, (3S)-;GTPL10646;SB19649;compound 15b [PMID: 28041831];D11318;(S)-ethyl 8-(2-amino-6-((R)-1-(5-chloro-[1,1'-biphenyl]-2-yl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-
SMILES:	ClC1=CC=C(C(=C1)C1C=CC=CC=1)[C@H](C(F)(F)F)OC1=CC(=NC(N)=N1)N1CCC2(CN[C@H](C(=O)OCC)C2)CC1
Formula:	C₂₉H₃₁ClF₃N₅O₃
M.Wt:	590.036356210709
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

KAR-5585 (Rodatristat) is the prodrug of the potent TPH1 inhibitor KAR5417, shows robust reduction of intestinal serotonin (5-HT) levels in mice; generates high and sustained systemic exposure of the active parent KAR5417 in rats and dogs; orally bioavailable. Hypertension Phase 1 Clinical

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