ML299(VU0463568)|cas 1426916-00-8|DC Chemicals

Cas No.:	1426916-00-8
Chemical Name:	ML-299
Synonyms:	Ml-299;ML299;4-bromo-N-{(2S)-1-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]propan-2-yl}benzamide;(S)-4-bromo-N-(1-(1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl)propan-2-yl)benzamide;MLS004084521;AOB4530;BDBM154517;SMR002881967;ML299 (5);VU0463568-2;MJY;4-Bromo-N-[(2S)-1-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]propan-2-yl]benzamide
SMILES:	BrC1C=CC(=CC=1)C(N[C@@H](C)CN1CCC2(C(NCN2C2C=CC=C(C=2)F)=O)CC1)=O
Formula:	C₂₃H₂₆BrFN₄O₂
M.Wt:	489.389
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	ML299 is a potent, CNS penetrant, dual phospholipase PLD1/PLD2 probe with IC50 of 6 nM/20 nM, respectively; robustly increases caspase 3/7 activation under serum-free conditions, provides a dose-dependent decrease (100 nM to 10 uM) in invasive migration in U87-MG cells, with statistical significance reached at both the 1 uM and 10 uM doses.
References:	References 1. Scott SA, et al. Nat Chem Biol. 2009 Feb;5(2):108-17. 2. O'Reilly MC, et al. J Med Chem. 2013 Mar 28;56(6):2695-9. 3. Scott SA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. View Related Products by Target Phospholipase

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ML-299