2BAct|cas 2143542-28-1|DC Chemicals

Cas No.:	2143542-28-1
Chemical Name:	2BAct
Synonyms:	2BAct\|eIF2B activator 2BAct
SMILES:	O=C(C1=NC=C(C(F)F)N=C1)NC2(C3)CC3(NC(COC4=CC=C(Cl)C(F)=C4)=O)C2
Formula:	C₁₉H₁₆ClF₃N₄O₃
M.Wt:	440.807
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

2BAct (eIF2B activator 2BAct) is a novel, highly selective, CNS-permeable small molecule eIF2B activator with EC50 of 33 nM in cell-based reporter assays; 2BAct normalized body weight gain and prevented motor deficits in male R191H mice, prevented myelin loss and reactive gliosis in the brain and spinal cord of R191H mice; also prevented ISR induction in the cerebellum and spinal cord of Eif2b5R132H/R132H mice, prevented all measures of pathology and normalizes the transcriptome and proteome of Vanishing White Matter (VWM) mice.

References:

References 1. Wong YL, et al. Elife. 2019 Jan 9;8. pii: e42940. doi: 10.7554/eLife.42940. View Related Products by Target Eukaryotic Initiation Factor (eIF)

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