MF-766|CAS 1050656-06-8|DC Chemicals

Cas No.:	1050656-06-8
Chemical Name:	4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-carboxamido)cyclopropyl)benzoic acid
Synonyms:	MF-766\|MF766;MF 766
SMILES:	O=C(O)C1=CC=C(C2(NC(C3=CC=CC4=C3N(CC5=CC=C(C(F)(F)F)C=C5)C=C4)=O)CC2)C=C1
Formula:	C₂₇H₂₁F₃N₂O₃
M.Wt:	478.471
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	Colucci J, et al. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3760-3. View Related Products by Target Prostaglandin Receptor

Description:

MF-766 (MF766) is a highly potent and selective EP(4) antagonist with binding Ki of 0.23 nM, displays no significant affinity (>7000-fold selectivity) against other PG receptors (IC50>1500 nM); behaved as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay; exhibits blockade of inhibition of TNFa-induced IP10 release by the specific EP4 agonist L-000902688 (IC50=9.5 nM); demonstrates potency and efficacy of in the rat AIA model measuring inhibition of paw swelling.

References:

References 1. Colucci J, et al. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3760-3. View Related Products by Target Prostaglandin Receptor

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