inh-02 |CAS 324579-65-9|DC Chemicals

Cas No.:	324579-65-9
Chemical Name:	(E)-N-((Z)-4-benzyl-3-methyl-1,2,4-thiadiazol-5(4H)-ylidene)-N'-phenylbenzimidamide
Synonyms:	inh-02\|RNF5 inhibitor inh-02
SMILES:	CC1=NS/C(N1CC2=CC=CC=C2)=N\C(C3=CC=CC=C3)=N\C4=CC=CC=C4
Formula:	C₂₃H₂₀N₄S
M.Wt:	384.501
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

inh-02 (RNF5 inhibitor inh-02) is a novel small molecule inhibitor of E3 ubiquitin ligase RNF5/RMA1; causes significant F508del-CFTR rescue (EC50=2.2 uM) in immortalized and primary bronchial epithelial cells from CF patients homozygous for the F508del mutation, decreases ubiquitylation of mutant CFTR, causing stabilization of the mature form of CFTR; inh-2 acts on ATG4B and paxillin, which are known targets downstream of RNF5.

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RNF5 INHIBITOR INH-02