N-65828|CAS 501444-06-0|NSC-65828

Cas No.:	501444-06-0
SMILES:	O=C1C=CC(=C2C=CC(=NNC3C=CC(N)=C4C=C(S(=O)(O)=O)C=CC=34)C=C2)C=C1 \|c:4,t:8\|
Formula:	C₂₂H₁₇N₃O₄S
M.Wt:	419.453083753586
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity-PNAS-July 23, 2002 vol. 99 no. 15

Description:

NCI-65828 (designated as N 65828) is a small-molecule inhibitor targeting angiogenin (ANG), a protein critical for angiogenesis and cellular proliferation. Its therapeutic potential stems from selective suppression of ANG's ribonucleolytic function, a biochemical activity essential for mediating downstream biological effects. By disrupting ANG's enzymatic capacity to cleave RNA substrates, NCI-65828 attenuates the protein's pro-angiogenic signaling pathways. Preclinical evaluations highlight its multifaceted antitumor properties. In vitro studies using diverse cancer cell models—including bladder carcinoma (T24; IC₅₀ = 1.3 ± 0.5 μM), cervical adenocarcinoma (HeLa; IC₅₀ = 1.9 ± 0.4 μM), and urothelial carcinoma (UROtsa; IC₅₀ = 3.2 ± 0.8 μM)—demonstrate dose-dependent antiproliferative effects, with potency variations reflecting tissue-specific sensitivity. Parallel experiments in human umbilical vein endothelial cells (HUVECs) reveal significant inhibition of capillary-like tube formation, confirming its antiangiogenic efficacy in disrupting endothelial morphogenesis. Notably, in vivo investigations using transgenic murine models demonstrate that NCI-65828 effectively suppresses the development of prostatic intraepithelial neoplasia (PIN) lesions. Mechanistic analysis indicates this activity arises from direct enzymatic inhibition rather than interference with ANG's intracellular trafficking, as nuclear translocation remains unaffected—a distinguishing feature that differentiates it from other ANG-targeted agents. This selective mode of action positions NCI-65828 as a precision tool for studying ANG-dependent pathologies.

References:

A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity-PNAS-July 23, 2002 vol. 99 no. 15

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