SZL P1-41| CAS 222716-34-9|DC Chemicals

Cas No.:	222716-34-9
Chemical Name:	4H-1-Benzopyran-4-one, 3-(2-benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-
SMILES:	O=C1C2C(=C(C(=C(C=2)CC)O)CN2CCCCC2)OC=C1C1SC2C(=CC=CC=2)N=1
Formula:	C₂₄H₂₄N₂O₃S
M.Wt:	420.524
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Chan CH et al. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell. 2013 Aug 1;154(3):556-68. [2]. Chan CH, et al. Skp2: a dream target in the coming age of cancer therapy. Cell Cy

Description:	SZL P1-41 is Skp2 inhibitor, selectively suppresses Skp2 E3 ligase activity, but not activity of other SCF complexes.
In Vivo:	SZL P1-41 exhibits potent anti-tumor activities in multiple animal models and cooperates with chemotherapeutic agents to reduce cancer cell survival.
In Vitro:	SZL P1-41 also phenocopies the effects observed upon genetic Skp2 deficiency, such as suppressing survival, Akt-mediated glycolysis as well as triggering p53-independent cellular senescence. SZL P1-41 prevent Skp2-Skp1 interactions and Skp2 SCF E3 ligase activity. The reference concentration is 5 uM. SZL P1-41 restricts cancer cell survival through triggering p53-independent cellular senescence and inhibiting aerobic glycolysis.

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