ML359| CAS 1069858-99-6|DC Chemicals

Cas No.:	1069858-99-6
Chemical Name:	ML359
Synonyms:	ML359;Ethyl N-(7-Methoxy-1-methylpyrazolo[3,4-b]quinolin-3-yl)furan-2-carboxamide;BCP33229
SMILES:	O1C=CC=C1C(N(CC)C1C2=CC3C=CC(=CC=3N=C2N(C)N=1)OC)=O
Formula:	C₁₉H₁₈N₄O₃
M.Wt:	350.371223926544
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Khodier C, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

Description:	ML359 is a small molecule, specific inhibitor of Protein disulfide isomerase (PDI) with IC50 of 250 nM; displays >100-fold selectivity over other thiol isomerases (Erp5, Thioredoxin, Thioredoxin reductase); shows no cytotoxicity in three human cell lines, and some activity in inhibiting platelet aggregation in vitro.
References:	References 1. Khodier C, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. View Related Products by Target Protein Disulfide Isomerase (PDI)

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