CPYPP| CAS 310460-39-0|DC Chemicals

Cas No.:	310460-39-0
Chemical Name:	Cpypp
Synonyms:	CPYPP;4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione;(4Z)-4-[(E)-3-(2-chlorophenyl)prop-2-enylidene]-1-phenylpyrazolidine-3,5-dione
SMILES:	ClC1C=CC=CC=1/C=C/C=C1/C(NN(C/1=O)C1C=CC=CC=1)=O
Formula:	C₁₈H₁₃ClN₂O₂
M.Wt:	324.761023283005
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

CPYPP is a small-molecule inhibitor of the Rac activator DOCK2 with IC50 of 22.8 uM (DOCK2DHR-2-mediated Rac GEF activity), inhibits DOCK2-Rac1 interaction; binds to DOCK2 DHR-2 domain in a reversible manner and inhibited its catalytic activity in vitro; blocks both chemokine receptor- and antigen receptor-mediated Rac activation in lymphocytes, resulting in marked reduction of chemotactic response and T cell activation.

References:

References 1. Nishikimi A, et al. Chem Biol. 2012 Apr 20;19(4):488-97. 2. Watanabe M, et al. J Immunol. 2014 Dec 1;193(11):5660-7. View Related Products by Target Small GTPase

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