KL001(KL-001;KL 001)| CAS 309928-48-1|DC Chemicals

Cas No.:	309928-48-1
Chemical Name:	N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide
SMILES:	CS(=O)(N(CC(O)CN1C2=C(C3=C1C=CC=C3)C=CC=C2)CC4=CC=CO4)=O
Formula:	C₂₁H₂₂N₂O₄S
M.Wt:	398.48
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Hirota T, et, al. Identification of small molecule activators of cryptochrome. Science. 2012 Aug 31;337(6098):1094-7. [2]. Kelleher FC, et, al. Circadian molecular clocks and cancer. Cancer Lett. 2014 Jan 1;342(1):9-18. [3]. Nangle S, et, al. Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase. Cell Res. 2013 Dec;23(12):1417-9.

Description:	KL001 is a cryptochrome protein (CRY) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis[1][2].
In Vitro:	KL001 (0.03-71 μM) causes circadian period lengthening and amplitude reduction in a dose-dependent manner in stable U2OS reporter cell lines harboring Bmal1-dLuc or Per2-dLuc[1]. KL001 (2-8 μM; 18 h) represses glucagon-dependent induction of Pck1 and G6pc genes in a dose-dependent manner without affecting their basal expression in mouse primary hepatocytes[1].
References:	[1]. Hirota T, et, al. Identification of small molecule activators of cryptochrome. Science. 2012 Aug 31;337(6098):1094-7. [2]. Kelleher FC, et, al. Circadian molecular clocks and cancer. Cancer Lett. 2014 Jan 1;342(1):9-18.

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