IU1-47| CAS 670270-31-2|DC Chemicals

Cas No.:	670270-31-2
Chemical Name:	1-(1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1yl)ethanone
Synonyms:	IU1-47;IU1 47;IU147
SMILES:	CC1=CC(C(CN2CCCCC2)=O)=C(C)N1C3=CC=C(Cl)C=C3
Formula:	C₁₉H₂₃ClN₂O
M.Wt:	330.856
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Boselli M, et al. J Biol Chem. 2017 Nov 24;292(47):19209-19225.

Description:	IU1-47 is a potent USP14 inhibitor with an IC50 of 0.6 μM. IU1-47 induces tau elimination in cultured neurons[1].
References:	[1]. Boselli M, et al. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. J Biol Chem. 2017 Nov 24;292(47):19209-19225.

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