AY-9944| CAS 366-93-8|DC Chemicals

Cas No.:	366-93-8
Chemical Name:	trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride
Synonyms:	AY9944;AY 9944,AY-9944
SMILES:	Cl.ClC1=CC=CC=C1CNCC1CCC(CNCC2=CC=CC=C2Cl)CC1
Formula:	C₂₂H₂₈Cl₂N₂^.₂HCl
M.Wt:	464.3
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

AY-9944 is a cholesterol biosynthesis inhibitor that targets the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM), attenuates of Smoothened-dependent and -independent Hh signaling; has been used to recapitulate phenotypes of Smith-Lemli-Opitz syndrome in animal model.

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