NVP-BGJ398 phosphate| CAS 1310746-10-1

Cas No.:	1310746-10-1
Chemical Name:	Infigratinib phosphate
Synonyms:	NVP BGJ398 phosphate;BGJ-398 phosphate;Infigratinib phosphate;N'-(2,6-Dichloro-3,5-dimethoxyphenyl)-N-[6-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-N-methylurea phosphate (1:1);NVP-BGJ398 (phosphate);58BH47BV6S;3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea phosphate;Infigratinib phosphate (USAN);Infigratinib phosphate [USAN];Urea, N'-(2,6-dichloro-3,5-dimethoxyphenyl)-N-(6-((4-(4-ethyl-1-piperazinyl)phenyl)amino)-4-pyrimidinyl)-N-methyl-, phosphate (1:1);Infigratinib monophosphate;Urea, N'-(2,6-dichl
SMILES:	ClC1C(=C([H])C(=C(C=1N([H])C(N(C([H])([H])[H])C1C([H])=C(N=C([H])N=1)N([H])C1C([H])=C([H])C(=C([H])C=1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])=O)Cl)OC([H])([H])[H])OC([H])([H])[H].P(=O)(O[H])(O[H])O[H]
Formula:	C₂₆H₃₄Cl₂N₇O₇P
M.Wt:	658.4706
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

NVP-BGJ398 phosphate (Infigratinib phosphate, BGJ398 phosphate) is a potent, selective pan-FGFR inhibitor with IC50 of 0.9/1.0/1.4/60 nM for FGFR1/2/3/4, also shows high potenct against mutant FGFR3-K650E with IC50 of 4.9 nM; inhibits the proliferation of the FGFR1-, FGFR2-, and FGFR3-dependent BaF3 cells with IC50 of low nanomolar range; shows significant antitumor activity in RT112 bladder cancer xenografts models overexpressing wild-type FGFR3, significantly inhibits the growth of FGFR2-mutated endometrial cancer xenograft models, also ameliorates FGF23-mediated hypophosphatemic rickets in mouse models.Blood CancerPhase 2 Clinical

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