Doxapram|CAS 1015064-87-5|DC Chemicals

Cas No.:	309-29-5
Chemical Name:	1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one
Synonyms:	1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one;1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one;Doxapram;Dopram;Doxapram HCL;doxapram hydrochloride;Doxapramum;1-Ethyl-4-(2-morpholin-4-ylethyl)-3,3-di(phenyl)pyrrolidin-2-one
SMILES:	O=C1N(CC)CC(CCN2CCOCC2)C1(C3=CC=CC=C3)C4=CC=CC=C4
Formula:	C₂₄N₂O₂H₃₀
M.Wt:	378.5072
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Doxapram inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.

References:

[1]. Cotten JF, et al. The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration. Anesth Analg, 2006, 102(3), 779-785. [2]. Peers, C., Effects of doxapram on ionic currents recorded in isolated type I cells of the neonatal rat carotid body. Brain Res, 1991. 568(1-2): p. 116-22. [3]. Anderson-Beck, R., et al., Doxapram stimulates dopamine release from the intact rat carotid body in vitro. Neurosci Lett, 1995. 187(1): p. 25-8.

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