IMTPPE|SID 3712502|DC Chemicals

Cas No.:	851688-13-6
Chemical Name:	2-(((3,5-Dimethylisoxazol-4-yl)methyl)thio)-1-(4-(2,3-dimethylphenyl)piperazin-1-yl)ethan-1-one
Synonyms:	SID 3712502,IMTPPE
SMILES:	O=C(N1CCN(C2=CC=CC(C)=C2C)CC1)CSCC3=C(C)ON=C3C
Formula:	C₂₀H₂₇N₃O₂S
M.Wt:	373.1824
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	. 2020 Jan;19(1):75-88. doi: 10.1158/1535-7163.MCT-19-0489. Epub 2019 Sep 25.

Description:

IMTPPE (SID 3712502) is a novel small molecule capable of inhibiting androgen receptor (AR) transcriptional activity (IC50=1 uM) and protein level in C4-2 prostate cancer cells; IMTPPE inhibited proliferation of AR-positive, but not AR-negative, prostate cancer cells in culture. IMTPPE inhibited the transcriptional activity of a mutant AR lacking the ligand-binding domain (LBD); IMTPPE inhibited the growth of 22Rv1 xenograft tumor, a model for enzalutamide-resistant prostate cancer.

References:

A Novel Small Molecule Targets Androgen Receptor and Its Splice Variants in Castration-Resistant Prostate Cancer---Mol Cancer Ther . 2020 Jan;19(1):75-88. doi: 10.1158/1535-7163.MCT-19-0489. Epub 2019 Sep 25.

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