MKK7-COV-3|MKK7 Covalen inhibitor 3|DC Chemicals

Cas No.:
Chemical Name:	N-(3-(6-methyl-1H-indazol-3-yl)phenyl)acrylamide
Synonyms:	MKK7-COV-3\|MKK7 Covalen inhibitor 3
SMILES:	C(NC1=CC=CC(C2C3=C(NN=2)C=C(C)C=C3)=C1)(=O)C=C
Formula:	C₁₇H₁₅N₃O
M.Wt:	277.327
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

MKK7-COV-3 (MKK7 Covalen inhibitor 3) is a potent, selective, covalent MKK7 inhibitor with in vitro IC50 of 5 nM, displays >1,000-fold selectivity over MKK4 (IC50=7.81 uM), shows EC50 of 1.3 uM for reduction of p-JNK in ICW assays in Beas2B cell line, without effect on p-ERK levels at 10 uM; displays remarkable selectivity against a kinome panel of 76 kinases, with very few kinases inhibited by more than 75% at 1 uM: Aurora kinase B, LRRK2, and MKK4, as well as FLT3; inhibits 60% of the CD86+ response in primary mouse B cells in response to LPS stimulation (10 μM, 2 hr pre-incubation).

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