Prednisolone phosphate sodium|CAS 125-02-0|DC Chemicals

Cas No.:	125-02-0
Chemical Name:	prednisolone 21-(disodium phosphate)
Synonyms:	prednisolone 21-(disodium phosphate);Prednisolone Sodium Phosphate;Prednisoline 21-phosphonic acid disodium salt;Disodium Prednisolone 21-Phosphate;Prednisolone (disodium phosphate);Prednisolone 21-phosphate disodium;Prednisolone Phosphate (sodium salt);Prednisolone phosphate sodium;Sodiumprednisolone-21-phosphate;(11beta);Ak-pred;codelsol;Dojilon;inflamase;Metreton;optival;prednisolon disodium phosphate;prednisolone 21-disodium phosphate;Prednisolone 21-Phosphate Disodium Salt;predsol;prozorin;solucort;Prednisolone 21-phosphate disodium salt;(11b)-11,17-Dihydroxy-21-(phosphonooxy)-pregna-1,4-diene-3,20-dione disodium salt;Disodium prednisolone 21-phosphate;(11beta)-
SMILES:	[Na+].[Na+].O=P(OCC([C@]1(CC[C@H]2[C@@H]3CCC4=CC(C=C[C@]4(C)C3C(C[C@]12C)O)=O)O)=O)([O-])[O-]
Formula:	C₂₁H₂₇Na₂O₈P
M.Wt:	484.387589693069
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.Prednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity. Prednisolone can activate and influence biochemical behaviour of most cells. The steroid/receptor complexes dimerise and interact with cellular DNA in the nucleus, binding to steroid-response elements and modifying gene transcription. They induce synthesis of some proteins, and inhibit synthesis of others. Prednisolone exerted a delayed biphasic effect on the resistant CCRF-CEM leukemic cell line, necrotic at low doses and apoptotic at higher doses. At low doses, prednisolone exerted a pre-dominant mitogenic effect despite its induction on total cell death, while at higher doses, prednisolone's mitogenic and cell death effects were counterbalanced [1, 2].
Target:	Glucocorticoid Receptor
References:	[1]. Lambrou, G.I., et al., Prednisolone exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells: Relation to early gene expression. Leuk Res, 2009. 33(12): p. 1684-95. [2]. http://en.wikipedia.org/wiki/Prednisolone

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