SM-7368|CAS 380623-76-7|DC Chemicals

Cas No.:	380623-76-7
Chemical Name:	3-Chloro-4-nitro-N-(5-nitro-1,3-thiazol-2-yl)benzamide
Synonyms:	SM-7368; SM 7368; SM7368; NF-kappaB Activation Inhibitor III
SMILES:	O=C(NC1=NC=C([N+]([O-])=O)S1)C2=CC=C([N+]([O-])=O)C(Cl)=C2
Formula:	C₁₀H₅ClN₄O₅S
M.Wt:	328.68
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	SM-7368 inhibits TNF-alpha-induced MMP-9 upregulation in a concentration-dependent manner. SM-7368 strongly inhibits the TNF-alpha-induced invasion of HT1080 human fibrosarcoma cell line.
Target:	NF-κB MMP-9 p38 MAP kinase
In Vitro:	SM-7368 (5 μM) targets downstream of MAPK p38 activation in the human colon derived crypt like HT-29 and Caco-2 epithelial cell lines[1]. SM-7368 inhibits TNF-α-induced MMP-9 upregulation in a concentration-dependent manner and shows maximal activity at 10 μM. SM-7368 inhibits TNF-α-induced MMP-9 mRNA transcript accumulation and protein expression. SM-7368 strongly inhibits TNF-α-induced NF-κB activity but not AP-1 activity. SM-7368 strongly inhibits the TNF-α-induced invasion of HT1080 human fibrosarcoma cell line[2]. SM-7368 (10-25 μM) greatly inhibits TNF-α (20 ng/mL)-induced MMP-9 upregulation. 10 μM of SM-7368 almost completely abrogates this upregulation[2]. Western Blot Analysis[2] Cell Line: HT1080 human fibrosarcoma cells Concentration: 0, 1, 5, 10, 15, 20, and 25 μM Incubation Time: 24 hours Result: Greatly inhibited TNF-α (20 ng/mL)-induced MMP-9 upregulation in a concentration-dependent manner.
References:	[1]. Sabine Kuntz, et al. Carbonyl compounds methylglyoxal and glyoxal affect interleukin-8 secretion in intestinal cells by superoxide anion generation and activation of MAPK p38. Mol Nutr Food Res. 2010 Oct;54(10):1458-67. [2]. Ha Young Lee, et al. A small compound that inhibits tumor necrosis factor-alpha-induced matrix metalloproteinase-9 upregulation. Biochem Biophys Res Commun. 2005 Oct 21;336(2):716-22.

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