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DSPE-PEG-N3（DSPE-PEG-Azide, MW2000)

  Cat. No.:  DC66293   Featured
Chemical Structure
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More than 5000 active chemicals with high quality for research!
Field of application
DSPE-PEG-N3 is a click chemical PEG reagent. Azide group is easy to react with alkynyl group under the catalysis of copper catalyst. It can also react directly with DBCO without any catalyst. DSPE (1,2-distearoyl-sn-glycerol-3-phosphoethanolamine) is a saturated 18 carbon phospholipid, which is commonly used in the synthesis of liposomes. Polyethylene glycol (PEG) - coupled DSPE is hydrophilic and can be used for drug delivery, gene transfection and biomolecular modification. The PEG of phospholipid significantly improved the blood circulation time and stability of the capsule drug. Polyethylene glycol can enhance the solubility and stability, reduce the non-specific binding of charged molecules on the surface, and reduce the immunogenicity of polypeptides. Azide (- N3) can react with copper catalyzed alkynes in aqueous solution and be reduced to amino groups. Polyethylene glycol can increase solubility and stability. It can also inhibit the nonspecific binding of charged molecules on the modified surface.
Chemicals PropertiesBiological activity Related products COA MSDS Datasheet
Cas No.:
Chemical Name: DSPE-PEG-N3（DSPE-PEG-Azide, MW2000)
SMILES: CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)([O-])OCCNC(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])OC(=O)CCCCCCCCCCCCCCCCC.[Na+]
Formula: C96H188O36N4PNa
M.Wt: 2028.52
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Cat. No. Product name Field of application
DC68215 DSG-PEG3400-N3 DSG-PEG3400-N3 is a conjugate composed of DSG, PEG chains, and terminal azido groups (-N3). DSG-PEG3400-Azide is a click chemistry reagent used for the targeted modification of liposomes/nanoparticles.
DC68214 DSG-PEG3400-Mal DSG-PEG3400-Mal is a conjugate composed of DSG, PEG chains, and maleimide (Mal). The maleimide group in DSG-PEG3400-Mal can undergo a specific Michael addition reaction with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers), enabling targeted modification of liposomes/nanoparticles.
DC68163 DSPE-PEG-DSS6 DSS6-PEG-DSPE,DSPE-PEG-DSS6 is a composite molecule composed of phospholipids(DSPE),polyethylene glycol(PEG),and bone targeting peptide DSS6,mainly used for bone targeted drug delivery and bone tissue repair. Its core structure achieves precise targeting and efficient delivery through the synergistic effect of three parts.The DSS6 peptide consists of six Asp-Ser-Ser amino acid repeat sequences and can specifically recognize hydroxyapatite(HAp)in bone tissue.
DC68155 DMG-PEG2000-Biotin DMG-PEG2000-Biotin is a synthetic amphiphilic molecule composed of dimyristoyl glycerol (DMG), polyethylene glycol (PEG2000), and biotin functionalities. It is commonly employed in biomedical research for surface modification of lipid-based delivery platforms, such as lipid nanoparticles (LNPs) and liposomes. The PEG moiety enhances colloidal stability, prolongs circulation time, and reduces rapid clearance in vivo. The biotin termination facilitates conjugation to streptavidin-tagged biomolecules, exploiting the highly specific biotin-streptavidin interaction. Thus, DMG-PEG2000-Biotin is valuable for drug-delivery optimization, targeted therapeutic approaches, and in vitro diagnostic assay development.
DC68154 Thiol-PEG2000-DMG Thiol-PEG2000-DMG is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. The terminal thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc.
DC68153 DMG-PEG2000-OH DMG-PEG2000-OH is a PEG derivative that can be used to construct drug delivery vehicles.
DC68152 DMG-PEG2000-SH DMG-PEG2000-SH is a PEG derivative that can be used to construct drug delivery vehicles.
DC67619 DMG-PEG-TCO (MW2000) DMG-PEG2000-TCO offer the ability to easily conjugate to specific biomolecules via metal free click chemistry to tetrazines. By changing the PEG length, one can change the micelle size, immunological safety, and change the drug release rate.
DC67603 DMG-PEG-Mal, MW 2,000 DMG-PEG-Mal, MW 2,000 is a lipid PEG consisting of DMG and maleimide for reacting with thiols between pH 6.5 to 7.5
DC67571 DMG-PEG-Mannose DMG-PEG-Mannose is a specialized functionalized lipid used primarily for the targeted delivery of lipid nanoparticles (LNPs) and liposomes to cells expressing mannose receptors, such as macrophages and dendritic cells. It combines a 1,2-dimyristoyl-sn-glycerol (DMG) lipid anchor with a polyethylene glycol (PEG) spacer and a terminal mannose sugar moiety.
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Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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