KR31173|CAS 260554-07-2|DC Chemicals

Cas No.:	260554-07-2
Chemical Name:	KR31173
SMILES:	[O-][N+]1=CC=CC=C1C2=C(COC)N=C(N(CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3)C(CCCC)=N6)C6=C2
Formula:	C₃₁H₃₀N₈O₂
M.Wt:	546.62
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC7224	PD 123319	PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.
DC4210	Azilsartan kamedoxomil	Azilsartan medoxomil is an angiotensin II receptor antagonist indicated for the treatment of mild to moderate essential hypertension.
DC76423	KR31173	KR31173 is an AT1 antagonist with an IC50 of 3.27  nM. KR31173 can be used as a positron emission tomography (PET) tracer after being labeled with 11C isotope. KR31173 shows promising biodistribution and pharmacological properties in mice. KR31173 selectively binds to organs known to contain a high density of AT1 angiotensin receptors in CD-1 mice.
DC73383	Forasartan	Forasartan (SC-52458) is a potent, specific, competitive and reversible angiotensin II receptor (AT1 receptor) antagonist with binding Ki value of 2.9 nM.
DC71766	EMD 66684	EMD 66684 is an antagonist of Angiotensin II Type 1 (AT1) receptor. EMD 66684 shows potent binding affinities for the AT1 subtype Ang II receptor with an IC50 value of 0.7 nM. EMD 66684 also serves as an antiischemic cytoprotectant -.
DC70345	DCP1-3	DCP1-3 is a novel allosteric ligand of the angiotensin receptor AT1R, displays NAM potency on AngIV with IC50 of 0.29 uM.DCP1-3 reduces AngII-induced contraction in renal and iliac arteries in mice.DCP1-3 inhibits IgG binding to HEK-AT1R cells with IC50 of 2.9 nM.DCP1-3 reverses PAM effect of the IgG on the agonist-induced calcium response.
DC48150	Mopivabil	Mopivabil is the antagonist of angiotensin II receptor.
DC48149	Mepixetil	Mepixetil is a potent antagonist of angiotensin II receptor.
DC48148	Azilsartan mopivabil	Azilsartan mopivabil is the potent antagonist of angiotensin II receptor.
DC48147	Azilsartan mepixetil	Azilsartan mepixetil is the antagonist of angiotensin II receptor. Azilsartan mepixetil has stronger and longer blood pressure effect, more abvious and longer lasting heart rate lowering effect and high safety. Azilsartan mepixetil achieves ideal protective effect for heart and kidney functions. Azilsartan mepixetil has the potential for the research of hypertension, chronic heart failure and diabetic nephropathy (extracted from patent CN107400122A).