L-369 (Lipid 369) |Ionizable Lipid for LNP

Cas No.:	1443522-24-4
Chemical Name:	L-369
SMILES:	C(OCCC(CCCCC)CCCCC)(=O)CCCCCCCC(OC(=O)CCCN(C)C)CCCCCCCC(OCCC(CCCCC)CCCCC)=O
Formula:	C₄₉H₉₅N₀₆
M.Wt:	794.28
Purity:	>95%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	Jadhav, V., Vaishnaw, A., Fitzgerald, K., et al. RNA interference in the era of nucleic acid therapeutics. Nat. Biotechnol. 42(3), 394-405 (2024).

Cat. No.	Product name	Field of application
DC57006	L319	L319 (LIPID 319) is a novel ionizable, biodegradable lipid for delivery of short interfering RNAs (siRNAs). L319-LPN displays rapid elimination with pKa of 6.38 and also shows well tolerated up to 10 mg/kg.
DC65412	Acuitas Lipid III-2	Acuitas Lipid III-2 is an ionizable amine lipid with two identical ester tails adjacent to C6 position relative to amine from patent:WO2017075531A1 with the similar activity as ALC-0315. The head of lipid is propanolamine which can effectively encapsulate mRNA used in gene therapies which depends on the availability of a safe and efficient delivery vehicle.
DC67212	Acuitas Lipid III-25	Acuitas Lipid III-25 is an novel ionizable amine lipid used for mRNA delivery from Acuitas Therapeutics patent US 10,166,298 B2, with pKa 6.22, Liver Luc 1648 for 0.3mgkg(ng luc/g liver), Liver Luc 13880 for 1mgkg(ng luc/g liver) . It is an analgous of ALC-0315, showing higher activity than ALC-0315.
DC65701	L-369	L-369 (Lipid 369,L369) is novel class of ionizable lipid for siRNA delivery with improved in vivo elimination profile with excellent translation across species,including NHP, wide safety margin.