(R)-N-Desmethyl PK11195|CAS 157809-85-3|DC Chemicals

Cas No.:	157809-85-3
Chemical Name:	3-Isoquinolinecarboxamide,1-(2-chlorophenyl)-N-[(1R)-1-methylpropyl]-
Synonyms:	3-Isoquinolinecarboxamide,1-(2-chlorophenyl)-N-[(1R)-1-methylpropyl]-;(R)-N-DESMETHYL PK11195, PRECURSOR FOR R-[N-METHYL-11C] PK11195;(R)-N-DESMETHYL PK 11195;1-(2-Chlorophenyl)-N-(1-methylpropyl)-isoquinoline-3-carboxamide;3-ISOQUINOLINECARBOXAMIDE, 1-(2-CHLOROPHENYL)-N-(1-METHYLPROPYL)-(R);N-Desmethyl-PK 11195;(R)-Desmethyl-PK11195;157809-85-3;124236-61-9;N-sec-Butyl-1-(2-chlorophenyl)isoquinoline-3-carboxamide;CIQM;CHEMBL179861;(S)-N-DESMETHYL PK 11195;XXSIYNJKCPZOFQ-UHFFFAOYSA-N;BDBM50180870;1-(2-chlorophenyl)-N-(1-methylpropyl)-3-isoquinoline carboxamide;1-[2-chlorophenyl]-N-[1-methyl-propyl]-3-isoquinoline carboxamide;N-butan-2-yl-1-(2-chlorophenyl)isoquinoline-3-carboxamide;N-(sec-Butyl)-1-(2-chlorophenyl)isoquinoline-3-carboxamide;SCHEMBL1170339;3-Isoquinolinecarboxamide, 1-(2-chlorophenyl)-N-(1-methylpropyl)-;3-Isoquinolinecarboxamide,1-(2-Chlorophenyl-N-[(1R-1-Methylpr
SMILES:	ClC1C=CC=CC=1C1C2C(=CC=CC=2)C=C(C(NC(C)CC)=O)N=1
Formula:	C₂₀H₁₉N₂OCl
M.Wt:	338.83066
Purity:	98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC67548	NOP-1A	NOP-1A standard. 11C-NOP-1A is a new radioligand for thenociceptin/orphanin FQ peptide (NOP) receptor, with high affinity (Ki, 0.15 nM) and appropriate lipophilicity (measured logD, 3.4) for PET brain imaging. 11C-NOP-1A is the the first successful radioligand to image NOP receptors in rat and monkey brain. 11C-NOP-1A is a selective antagonist at the NOP receptor and has high affinity and appropriate lipophilicity for blood–brain barrier permeability. 11C-NOP-1A imaging in rhesus monkeys showed high brain uptake and a large receptor-specific signal and could be quantified with the gold standard method of compartmental modeling. In humans 1C-NOP-1A reliably quantified NOP receptors in human brain both in large brain regions and at a voxelwise level using parametric imaging. The radiation absorbed dose in humans was similar to that observed with other 11C-labeled ligands and would allow multiple scans of a single subject. Thus, 11C-NOP-1A is a promising radioligand for reliably quantifying NOP receptors in human brain.
DC67547	NOP-1A Precursor	The Precursor of NOP-1A. (11)C-NOP-1A is a useful radioligand for quantifying NOP receptors in the monkey brain, and its radiation dose is similar to that of other (11)C-labeled ligands for neuroreceptors.
DC67437	PI-2620 precursor	PI-2620 precursor is the precursor of PI2620. 18F-PI-2620 is a PET tracer with high binding affinity for aggregated tau, a key pathologic feature of Alzheimer disease (AD) and other neurodegenerative disorders.
DC60818	mono-Boc-Br MK-6240 Precursor	mono-Boc-Br MK-6240 Precursor is the precusor of MK-6240.. (18)F]-MK-6240 is a tau positron emission tomography (PET) tracer for neurofibrillary tangles (NFTs), exhibiting high specificity and selectivity for binding to NFTs .
DC67285	DOTA-Octreotide
DC67284	NOTA-NOC
DC60791	Cholestify Precursor	Precursor of Cholestify,18F-Cholestify, which binds cytochrome P450 46A1, detected cholesterol breakdown in the mammalian brain. CYP46A1 converts cholesterol to 24-hydroxycholesterol, a form easily eliminated from the brain.
DC60790	DesMEM AZD4694	DesMEM AZD4694（AZD4694 Precursor 1）is the precursor of [18F] AZD4694 for the synthesis of [18F] AZD4694, an amyloid-β imaging ligand with high affinity for amyloid-β plaques.
DC66469	DOTA-NOC	DOTA-NOC (DOTA-Nal3-octreotide) is a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5. DOTA-NOC can be used for labeling with various radiometals, and development of radiopeptide imaging.
DC66468	NOTA-octreotide	NOTA-octreotide is a ligand for making [18F]AlF-NOTA-octreotide, which is a PET/CT imaging agent for somatostatin receptor imaging in neuroendocrine tumor patients