Novel inhibitor of TMPRSS2, also strongly preventing SARS-CoV-2 multiplication and CPE in Calu-3 cells in a dose-dependent manner. causing strong inhibition of SARS-CoV-2 replication

Novel Chemically Stable, Potent, and Efficacious MDM2 Inhibitor

Novel tyrosinase inhibitor, suppressing UVB-induced activation of NF-κB signaling pathway through the downregulation of oxidative stress

Novel tyrosinase inhibitor, directly inhibiting mushroom tyrosinase

Novel inhibitor of nitric oxide-induced melanogenesis, targeting the NO-induced cGMP signaling pathway

Novel inducer of G2/M phase arrest in the cell cycle progression, resulting in growth inhibition and induction of apoptosis in a concentration-dependent manner, and inhibition of proliferation in a time-dependent manner

Novel sensitizer of cancer cells, significantly increasing DNA damage as determined by DNA breakage, levels of damage-responsive proteins, and DNA foci

Novel tyrosinase inhibitor, down-regulating of MITF and tyrosinase through direct tyrosinase inhibition

Novel topoisomerase II inhibitor, markedly inducing apoptotic cell death via the mitochondria-mediated intrinsic pathway in LNCaP cells

Novel potent histone deacetylase (HDAC) inhibitor, inducing apoptosis via up-regulation of androgen receptor expression in human prostate cancer cells

Novel potent HDAC inhibitor, possessing potent anticancer activities

Novel tyrosinase inhibitor, showing concentration-dependent inhibitory effects with no significant cytotoxicity in cell viability assay

Novel photodynamic antitumor agent

Near-infrared cyanine dye, acting as an optical imaging agent

Potent and orally active group II mGluR antagonist with antidepressant-like potential

Selective metabotropic glutamate 2/3 receptor agonist

Novel, multi-targeted kinase inhibitor, demonstrating potent inhibition of Trk, RET and DDR, in addition to Met, Axl and VEGFRs

Novel potent negative allosteric modulator (NAM) of mGlu2

Novel Dual Fluorescent and Magnetic Resonance False Neurotransmitter

Radiographic Contrast Agent

Non-depolarizing muscle relaxant

Dopamine D2 antagonist, antiemetic

Highly Selective Class II MET Inhibitor

Peripherally restricted μ-opioid antagonist

Novel Class of Cannabinoid CB2 Receptor Inverse Agonist

Metablite of PRIMA-1 and APR-246, covalently binding to cysteine residues in mutant p53 and wild type p53, and being increased in unfolded p53, inducing massive apoptosis in p53 null tumor cells

Novel inhibitor of ABCG2 transporter function

Novel photosensitizer as a photodynamic antimicrobial agent against Staphylococcus aureus, Escherichia coli, Candida albicans, and Methicillin-resistant S. aureus (MRSA)

Useful pharmaceutical building block

Inhibitor of pro-inflammatory mediator release from mast cells