Novel third-generation EGFR tyrosine kinase inhibitor, targeting EGFR T790M mutation in advanced non-small cell lung cancer

Antibiotic, inhibiting bacterial protein synthesis

Natural alpha-aminobutyric acid-rich secondary metabolite of fungi, strongly inhibiting the BBMV V-ATPase, acting as a mitochondrial complex V inhibitor, showing antitumor activity in vivo

Calcium channel blocker, blocking both T-type and L-type calcium channels

Potent agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma) with potential antineoplastic activity

Novel eEF2K inhibitor, inducing significant apoptosis through classical apoptotic pathways

An impurity of Edoxaban, a novel inhibitor of factor Xa

Lipo-pro-prostaglandin E1, preventing hearing disturbance and equilibrium dysfunction due to inner ear microcirculatory disorders

Novel marine-derived anticancer saponin, targeting topoisomerase2alpha by unique interference with its DNA binding and catalytic cycle

Novel specific inhibitor of EcDsbB, targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria

Novel potent specific inhibitor of EcDsbB, targeting disulfide bond forming enzyme

Novel EBV activator, well-performing EBV lytic cycle inducer

Novel dose-dependent inhibitor of HDAC1, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9, inhibiting Pseudomonas aeruginosa alginate synthesis

Novel PP1-targeting Ebola Virus (EBOV) inhibitor with improved pharmacological properties

Novel Oral and Selective Prostaglandin F 2α (PGF 2α ) Receptor Antagonist

Highly potent and selective activator of isozymes CA-VA and CA-VII

Highly potent and selective activator of isozymes CA-VA and CA-VII

Novel degrader of GST-α and GST-α-EGFP fusion proteins as well as endogenous GST-π in cells and lysates

Sigma1 receptor ligand and potential atypical antipsychotic

Novel XIAP BIR2 domain-binding degrader of E3 ubiquitin ligases

Potent Activator of P53-Independent Cellular Senescence

γ-Secretase modulator (GSM) photoaffinity probe, revealing distinct allosteric binding sites on presenilin

Novel OPG/RANKL upregulator, increasing OPG expression without affecting RANKL expression, promoting osteoblast differentiation while inhibiting osteoclast differentiation, regulating OPG expression through canonical Wnt/β-catenin signaling

Novel potent Inhibitor of PI3Kalpha

Novel Selective and Potent EGFR Inhibitor, Overcoming T790M-Mediated Resistance in Non-Small Cell Lung Cancer

Antitumor antibiotic

Novel allosteric inhibitor of the tumor-promoting interaction between the oncogenic factor AIMP2-DX2 and HSP70

Novel Hsp70 agonist, showing no cellular toxicity and induced cellular stress response pathways

Novel and potent leukotriene B(4) receptor antagonist

Novel potent and highly selective inhibitor of VEGFR, exhibiting antitumor activities both in vitro and in vivo.