Novel specific bona fide EthR-inhibitor, boosting ETH 4 times in an intravenously infected TB mice model

Novel EthR inhibitor and ethionamide booster

Novel activator of ethionamide

Novel EthR inhibitor, boosting antituberculous activity of ethionamide

Potent and selective hydroxamate PfAM1 inhibitor

Sodium channel enhancer

Novel small molecule PTP1B inhibitor

Potent and selective

Novel Bcr-Abl inhibitor, potently inhibited Bcr-AblWT and Bcr-AblT315I kinases with IC 50 of 0.043 μM and 0.17 μM, respectively

Novel highly potent inhibitor of breakpoint cluster region-abelson kinase (Bcr-Abl) including the T315I mutant

Clearing cycloalkyne for click reaction with Azido-Warfarin WN3 or other Azido-containing drugs

Novel Cell-Permeable Probe for the Identification of Protein Sulfenic Acids

Novel B-Cell Lymphoma 6 (BCL6) PROTAC

Novel pan-Bcl-2 family inhibitor, upregulating the BH3-only protein Noxa, which inhibits Mcl-1, inducing autophagy through (ER) stress and disruption of the interaction of Beclin 1 with Bcl-2

Novel efficient Bcl-2 inhibitor, exhibiting high specificity and stabilizing effect toward G-quadruplexes

Novel potent and selective degrader of Bcl-2

Novel inhibitor of the KRS-67LR interaction

Novel butyrylcholinesterase inhibitor (BChEi) for the treatment of canine cognitive dysfunction

Memory Enhancer and Free Radical Scavenger

Novel FBXO7/PINK1 interaction antagonist, abrogating FBXO7 and PINK1 association, leading to increased cellular PINK1 concentrations and activities, and limiting mitochondrial damage

Novel potent inhibitor of IL-2 secretion, demonstrating potent immunomodulatory activity

Novel potent apoptotic inducer of human leukaemia cells by activation of the extrinsic pathway and the generation of reactive oxygen species

Novel inhibitor of SARS-CoV-2 main protease (MPro)

Potent inhibitor of LpxC

Novel potent TRPM8 antagonist (IC 50 1.25 ± 0.26 μM)

Novel inhibitor of prion replication

Selective inhibitor of type A monoamine oxidase with dopaminergic properties

Novel potent and selective acetyl-CoA carboxylase (ACC) inhibitor, blocking WNT3A lipidation, secretion, and signaling

Novel potent and selective acetyl-CoA carboxylase (ACC) inhibitor

Negaitve control for BAY-390