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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC70175 AEP07 Featured
AEP07 (AEP 07) is a selective small molecule inhibitor of PARP4 (vPARP) inhibitor with IC50 of 0.8 uM, >12-fold selective over other PARP family members.
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DC23260 NPD4456 Featured
A coumarin-based HIV-1 viral protein R (Vpr) inhibitor, inhibits Vpr-dependent viral infection of human macrophages..
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DC21995 AMXT-1501
AMXT-1501 (AMXT 1501, AMXT1501) is a novel potent polyamine transport inhibitor, synergistically reduces cell viability in NB cells in combination of with DFMO.
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DC21997 AP20187 Featured
AP20187 (AP-20187, AP 20187) is a cell-permeable, semisynthetic bivalent ligand (dimerizer) of FK506-binding protein (FKBP F36V).
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DC12422 JSH-150 Featured
JSH-150 (JSH150) is a potent, highly selective inhibitor of CDK9 kinase with IC50 of 1 nM in the biochemical assays, displays 300-10000-fold selectivity over other CDK kinase family members (CDK7 IC50=1.72 uM).
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DC11589 dBRD9 Featured
dBRD9 is a PROTAC that bridge the BRD9 bromodomain and the cereblon E3 ubiquitin ligase complex.
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DC71542 2-MPPA Featured
2-MPPA (GPI-5693) is an orally active and selective glutamate carboxypeptidase II (GCP II; PSMA) inhibitor with an IC50 of 90 nM.
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DC7495 SB-334867 HCl Featured
SB-334867 is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2.
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DC65676 Fenretinide Glucuronide Monosodium Salt Featured
Fenretinide Glucuronide Monosodium Salt, is the metabolite of Fenretinide (F250000), which is a synthetic retinoid deriverative, substances related to vitamin A. They are also shown to be used for the treatment of cancer, as well as in the treatment of cystic fibrosis, rheumatoid arthritis, acne, and psoriasis.
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DC70246 BFL-1 inhibitor 4E14 Featured
BFL-1 inhibitor 4E14 (4E14) is a potent, selective, covalent BFL-1 inhibitor that disrupt BH3-binding activity with IC50 of 1.3 uM, targets a unique C55 residue in the BFL-1 groove.4E14 blocks BFL-1 suppression of BAX-mediated mitochondrial apoptosis.
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DC11818 SCB-4380 Featured
SCB-4380 (SCB 4380, SCB4380) is the first potent, selective inhibitor for PTPRZ (protein tyrosine phosphatase receptor-type Z) with IC50 of 0.4 uM against human Z-ICR-catalyzed hydrolysis. SCB-4380 also strongly inhibits PTPRG (IC50=0.4 uM), and shows little inhibition on PTPRA, PTPRM, PTPRS, PTPRB, PTPN1 and PTPN6. SCB-4380 inhibites PTPRZ activity in C6 glioblastoma cells, and suppresse cell migration and proliferation in vitro and tumor growth in a rat allograft model.
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DC7709 ATN-161 Featured
ATN-161 is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model.
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DC23876 GSA-10 Featured
GSA-10 is a novel small-molecule positive modulator of Smoothened with EC50 of 1.2 uM in the differentiation assay.
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DC33707 Valinomycin Featured
Valinomycin is an cyclododecadepsipeptide ionophore antibiotic that acts as an insecticide and nematocide.
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DC22403 Casopitant mesylate Featured
Casopitant (GW679769) is a potent, centrally-acting neurokinin 1 (NK1) receptor antagonist (pKi=9.48) with antidepressant and antiemetic activities.
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DC4132 CP-547632 Featured
CP-547632 is as a potent inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases (IC50 11 and 9 nM, respectively).
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DC32961 PHA-543613 Featured
PHA-543613 acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors, with a high level of brain penetration and good oral bioavailability. It is under development as a possible treatment for cognitive deficits in schizophrenia.
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DC9325 Cilazapril (monohydrate) Featured
Cilazapril Monohydrate is a angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.
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DC7580 Naxagolide Featured
For the detailed information of Naxagolide, the solubility of Naxagolide in water, the solubility of Naxagolide in DMSO, the solubility of Naxagolide in PBS buffer, the animal experiment (test) of Naxagolide, the cell expriment (test) of Naxagolide, the in vivo, in vitro and clinical trial test of Naxagolide, the EC50, IC50,and Affinity of Naxagolide, Please contact DC Chemicals..
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DC45710 Pomalidomide-amino-PEG5-NH2 hydrochloride Featured
Pomalidomide-amino-PEG5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
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DC45712 Pomalidomide-amino-PEG3-NH2 hydrochloride Featured
Pomalidomide-amino-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
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DC65221 BAY-6096 Featured
BAY6096, a potent, selective, and highly water-soluble α2B antagonist with IC50 = 14 nM.
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DC33607 Myristoyl Pentapeptide-17 Featured
Myristoyl Pentapeptide-17 is small peptide. Myristoyl Pentapeptide-17 promotes the delivery of key ingredients for quicker lash growth, thus stimulates the hair growth at the follicle. Myristoyl Pentapeptide-17 effectively promotes the growth of eyelashes. It lengthens and thickens the eyelashes, fortifies the hair and noticeably intensifies eye expression.
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DC32408 Ac-beta-ala-his-ser-his-oh Featured
Eyeseryl, also known as Acetyl Tetrapeptide-5, humectant or hydroscopic moisturizer which helps reduce eye puffiness, improve skin elasticity as well as overall smoothness.
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DC26076 D-Ala2, D-Leu5-Enkephalin Featured
An angiotensin II analog that is an agonist of AT1 angiotensin receptor..
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DC32378 Palmitoyl pentapeptide Featured
Matrixyl, also known as Palmitoyl pentapeptide-4 (palmitoyl pentapeptide-3 before 2006) is a matrikine used in anti-wrinkle cosmetics. It was launched in 2000 as an active ingredient for the personal care industry under the trade name Matrixyl by the French cosmetic active ingredient manufacturer Sederma SAS.
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DC70135 Bremelanotide Featured
A peptide, non-selective melanocortin receptor agonist for treatment for female sexual dysfunction; selectively stimulates solicitational behaviors in the female rat, without affecting lordosis, pacing, or other sexual behaviors, does not cause generalized motor activation; a peptide analogue of α-MSH.
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DC32392 Afamelanotide Featured
Afamelanotide, also known as CUV1647, is a Melanocortin receptor agonist. Afamelanotide is a synthetic peptide and analogue of α-melanocyte stimulating hormone used to prevent skin damage from the sun in people with erythropoietic protoporphyria .It is under development in other skin disorders in several jurisdictions. It causes skin to turn darker by causing the skin to make more melanin.
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DC47396 Abaloparatide (BA058) Featured
Abaloparatide (BA058, BIM-44058, ITM-058) is a novel 34-amino acid peptide selected to be a potent and selective activator of the parathyroid hormone receptor (PTH1R) signaling pathway with an IC50 of 0.117 nM in SOST analysis.
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DC10241 Protirelin Featured
Protirelin is a tripeptide that stimulates the release of thyrotropin and prolactin.
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