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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC34502 SRT647
Nicotinamide Riboside is a precursor of NAD+ and a source of vitamin B3 (niacin). Nicotinamide Riboside increases intracellular and mitochondrial NAD+ content in C2C12.
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DC34486 Ac4ManNAz
Ac4ManNAz is a novel probe for metabolic labeling of sialoglycans, selectively imaging polysialic acids in neurons.
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DC34455 TP2
TP2 is an inhibitor of polyketide synthase 13 (Pks13), preventing synthesis of mycolic acid and resulting in mycobacterial cell death.
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DC34452 Aloenin
Aloenin is a moderate inhibitor of BACE.
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DC34416 Cirazoline Hydrochloride
Cirazoline HCl is a selective alpha1-adrenoceptor agonist and a non-selective imidazoline binding site ligand.
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DC34408 EBPC
EBPC is a potent aldose reductase inhibitor.
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DC34404 MDL-12330A
MDL-12330A is an inhibitor of adenylyl cyclase. It acts by inhibiting cAMP and cGMP phosphodiesterases and blocking slow extracellular and store-operated Ca2+ entry into cells.
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DC34380 SMI481
SMI481 is the first small-molecule inhibitor of Sec14-like phosphatidylinositol transfer proteins (PITPs).
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DC34377 Qc1
Qc1 is a reversible, non-competitive inhibitor of threonine dehydrogenase (TDH).
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DC34360 DNDS
DNDS is a voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR) channel blocker.
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DC34351 BRD32048
BRD32048 is an inhibitor of the ETV1 transcription factor oncoprotein.
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DC34247 TLCK hydrochloride
TLCK hydrochloride is a blocker of the LPS- or cytokine-induced activation of nuclear factor κB (NF-κB).
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DC34232 TPCK
TPCK is a non-specific irreversible inhibitor of serine/cysteine proteases. It acts by inhibiting ScRce1 in the presence of a Ras reporter, but not in the presence of the a-factor peptide.
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DC34219 MMV665852
MMV665852 is an antischistosomal agent. It has been shown to inhibit worm viability in vitro and reduce worm burden in S. mansoni-infected mice.
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DC34217 Proscillaridin
Proscillaridin, also known as Proscillaridin A, is a cardiotonic glycoside. It potently disrupts topoisomerase I and II activity.
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DC34174 DS2
DS2 is a selective positive allosteric modulator of d-GABAA receptors.
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DC34160 Lithocolic acid
Lithocolic acid is a bile acid formed from chenodeoxycholate by bacterial action. It acts as a detergent to solubilize fats for absorption and is itself absorbed.
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DC34123 Lentinan
Lentinan is an intravenous anti-tumor polysaccharide and one of the host-mediated anti-cancer drugs which has been shown to affect host defense immune systems.
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DC34112 PDBu
Phorbol 12,13-dibutyrate, also known as PDBu, is a phorbol ester which is one of the constituents of croton oil. As an activator of protein kinase C, it is a weak tumor promoter compared to 12-O-tetradecanoylphorbol-13-acetate.
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DC34108 Novokinin
Novokinin is an angiotensin AT2 receptor agonist. Novokinin exhibits vasorelaxing and hypotensive activity via activation of the IP (prostacyclin) receptor, and suppresses food intake via activation of PGE2-EP4 interaction.
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DC34098 NSC156529
NSC156529 downregulates AKT1 signaling, efficiently decreasing the proliferation of human cancer cells in vitro, and substantially inhibiting the growth of prostate tumor xenografts in vivo.
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DC34088 CCPA
CCPA, also known as 2-Chloro-N6-cyclopentyladenosine, is a centrally active, potent, and selective adenosine A1 receptor (ADORA1) agonist. In the lungs of mice and humans four adenosine receptors are expressed with different roles, having pro- and anti-inflammatory roles, determining bronchoconstriction and regulating lung inflammation and airway remodeling.
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DC34040 Bicuculline methiodide
Bicuculline methiodide is a GABA(A) receptor antagonist. Bicuculline methiodide attenuates inflammation by inhibiting the production of proinflammatory cytokines, such as tumor necrosis factor-alpha, and by increasing the production of the anti-inflammatory cytokine interleukin-10, both of which play important roles in the pathogenesis of sepsis.
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DC34020 (Z)-Guggulsterone
(Z)-Guggulsterone is a phytosteroid found in the resin of the guggul plant, Commiphora mukul. It acts as an antagonist of the farnesoid X receptor in humans.
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DC34002 Iodo-PEG3-Iodide
PEG3 diiodide is a homobifunctional linker with two iodide functional groups which are very reactive against many nucleophiles like thiols, amines, alkoxy anions, etc. Can be used to synthesize hydrophilic symmetrical conjugates.
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DC33827 Crotonic acid
Crotonic acid is a GABA analogue that inhibits GLIC function. It is used in the copolymerization of crotonic acid hydrogel systems by using gamma-rays.
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DC33826 Cyanoacetic acid
Cyanoacetic acid is used to produce vitamin B6 and caffeine. It is instrumental in making dyes, agricultural chemicals, and in the synthesis of phenylacetic acid esters
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DC33819 Perfluorobutyric acid
Perfluorobutyric acid is an ion pair reagent for reverse-phase HPLC. It is used in the sequencing, synthesis, and solubilizing of proteins and peptides.
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DC33794 Coprosterol
Coprosterol is a stanol formed from the biohydrogenation of cholesterol as a biomarker for the presence of human faecal matter in the environment.
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DC33774 Iprodione
Iprodione is a fungicide, bactericide, and wood preservative.
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