The first organ-selective thyromimetic, lowering plasma low density lipoprotein (LDL) cholesterol and raising plasma high density lipoprotein (HDL) cholesterol levels

Novel inhibitor of HIV-1 and SIV integrase

Chemically-modified forskolin with greater stability and water solubility than the parent compound

Novel HIV-1 integrase strand transfer inhibitor (INSTI), stabilizing an integrase-single blunt-ended DNA complex

Potent and selective agonist of the human beta3 adrenergic receptor

Class III antiarrhythmic agent, selectively blocking the slowly activating cardiac delayed rectifier potassium current Iks

Dual ET(A)/ET(B) endothelin receptor antagonist

Ras farnesyltransferase inhibitor, inhibiting in p70(s6k) phosphorylation in mammary tumors, inducing tumor regression in transgenic mice by mediating alterations in both cell cycle control and apoptosis

Potent glycoprotein IIb/IIIa inhibitor

Inhibitor of the KCNQ1 channel

Inhibitor of Strand Transfer, Preventing Integration and Inhibiting HIV-1 Replication in Cells

Inhibitor of Human Immunodeficiency Virus Type 1 (HIV-1)

HIV-1 non-nucleoside reverse transcriptase inhibitor

Novel partial agonist of muscarinic M1 receptors

HIV protease inhibitor

Potent, orally active monocyclic beta-lactam inhibitor of human polymorphonuclear leukocyte elastase (PMNL-E)

Novel partial agonist of the benzodiazepine receptor

Blocker of the activity of human neutrophil elastase (NE), human proteinase-3, human macrophage metalloelastase, mouse macrophage metalloelastase and Pseudomonas aeruginosa elastase

Potent leukotriene inhibitor

Novel potent inhibitor of human pancreatic cancer cells

Novel inhibitor of the TWEAK-Fn14 signaling cascade

Novel inhibitor of α-synuclein amyloid aggregation for the treatment of Parkinson's disease

Novel γ-secretase modulator photoaffinity probe, identifying distinct allosteric binding sites on presenilin that can be exploited to reduce levels of pathogenic Aβ species

Novel Migration Inhibitory Factor (MIF) inhibitor, binding at the allosteric and tautomerase sites, blocking MIF's tautomerase CD74 receptor binding, and pro-inflammatory activities

Novel cell-permeable attenuated cationic amphiphilic lytic (ACAL) peptide, efficiently bring immunoglobulin G (IgG) and other functional proteins into cells

Nonpeptide agonist of angiotensin AT1 receptor

Potent inhibitor of LpxC and lipid A biosynthesis

Selective T-type Ca(2+) channel blocker with anti-proliferative effects against various cancer cells

Novel inhibitor of the Wnt/ß-catenin pathway, binding directly to the regulators of G-protein signaling domain of axin, initiating ß-catenin and Ras degradation through enhancement of the ß-catenin destruction complex activating GSK3ß, effectively suppres

Ras destabilizer, targeting the Wnt/ß-catenin pathway and inhibiting development of metastatic colorectal cancer