Novel Potent Anticonvulsant Agent with In Vitro Neuroprotection

Anticholinergic agent

Novel anti-filariasis agent, being effective in killing Brugia malayi, B. pahangi, and Litomosoides sigmodontis worms

Inhibitor of TLR2-, TLR3-, TLR4- and TLR5-mediated TNF-α, IL-1β and IL-6

Novel potent and selective leucyl-tRNA synthetase inhibitor

Novel Neuraminidase (NA) inhibitor

Novel Anti-Wolbachia Agent with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis

DNA polymerase lambda and beta inhibitor

Novel inhibitor of the replication of a disease-causing polyomavirus in cell culture

Novel small molecule prodrug for use with SEAKER cells, exhibiting enhanced anticancer activity

Novel potent inhibitor of peroxiredoxin I (PrxI), increasing cellular ROS, leading to the activation of both mitochondria- and apoptosis signal-regulated kinase-1-mediated signaling pathways

Novel Metallo-β-lactamase Inhibitor

Novel agonist of AMPK signaling

Potent allosteric activator of the AMPK

Potent allosteric activator of AMPK

Novel rapid and specific inhibitor of electrophile-sensitive DEAD-box proteins with high selectivity over the wild-type enzyme

The most potent AMPA stabilizer

Potent A1/A2A adenosine receptor agonist, protecting against myocardial infarction

Light-activated DNA, RNA crosslinking agent

L-type calcium channel blocker

Inhibitor of the re-uptake of norepinephrine and serotonin, inhibiting N-methyl-D-aspartate (NMDA) receptors

Immunomodulator

NSAID (non-steroidal anti-inflammatory drug) and non selective COX inhibitor

Radiation-protective agent, causing splenic vasodilation and blocking autonomic ganglia

Cysteine trapping agent, protecting cysteines exposed to the aqueous environment from subsequently added mal-PEG

Specific transient receptor potential ankyrin 1 (TRPA1) antagonist

Novel vanilloid receptor TRPV1 modulator

Novel vanilloid receptor TRPV1 modulator

Vanilloid receptor TRPV1 antagonist

Novel highly specific phosphodiesterase 10A (PDE10A) ligand with good uptake in the striatum