Melatonin analogue, selectively binding on MT3 subsites

Active metabolite of diclofenac, targeting COX and CaMKIIα hub domain

Morin isomer, antioxidant

Metabolite of dantrolene

Novel potent and selective G protein-biased 5-HT 7 R Antagonist, significantly reducing self-grooming duration time to the level of wild-type mice

Novel selective 5-HT 2C agonist with >300-fold functional selectivity over 5-HT 2B and >70-fold functional selectivity over 5-HT 2A , reducing food intake in an acute rat feeding model

Serotonin metabolite, systemically inhibiting RAS/MAPK signaling in different organs of C. elegans

Novel palladium-activated 5-FU prodrug, being completely innocuous to cells and highly resistant to metabolization by primary hepatocytes and liver S9 fractions (the main metabolic route for 5-FU degradation), and rapidly converted into 5-FU in the presen

Rare base found in mammalian DNA, having functional roles in DNA that go beyond being a demethylation intermediate

HIV-1 integrase inhibitor

Novel HIV-1 integrase inhibitor

Novel potent δ-selective allosteric modulator, Ki(α4β1δ) 0.14 µM

Novel potent δ-selective allosteric modulator, Ki(α4β1δ) 0.06 µM

Brominated luciferin, being more cell permeant than luciferin

Adenosine kinase inhibitor

Novel Inducer of G2/M arrest, Apoptosis and Autophagy in Cancer Cells

Novel inhibitor of HCV NS3-NS4A Serine Proteinase

Inhibitor of T-type voltage-gated calcium channels (Cav3), inhibiting isoforms Cav3.1, Cav3.2, and Cav3.3, decreasing nifedipine-resistant phenylephrine-induced vasoconstriction via Cav3.2 blockade

Bulding Block

Useful pharmaceutical building block

Useful pharmaceutical building block

Inhibitor of Androgen_receptor>androgen receptor (AR) transcriptional activity, more effective than resveratrol in inhibiting AKT>Akt phosphorylation

Novel anti-austerity agent, inducing PANC-1 human pancreatic cancer cell death under nutrition starvation via inhibition of Akt/mTOR pathway

Novel ligand for LTA4H, dose responsively reducing LTB4 production in human neutrophils

Novel Potent and Selective Kappa Opioid Receptor Antagonist

Dopamine reuptake inhibitor

Potent agonist of tropomyosin-receptor-kinase B (TrkB) receptor, possessing robust anti-apoptotic activity, promoting neurogenesis, and exhibiting potent antidepressant effect

Potent Antifungal Inhibitor of Chitin Synthesis

Novel selective ligand of the Transport Inhibitor Resistant 1 (TIR1)

Prodrug of 7-Cl-kynurenic acid (7-Cl-KYNA), a potent, selective antagonist of the NMDA/glycine receptor