98N12-5|Ionizable Lipid for LNP

Cas No.:	917572-74-8
Chemical Name:	98N12-5
Synonyms:	4,7,10,13-Tetraazahexadecanediamide, N1,N16-didodecyl-4,7,13-tris[3-(dodecylamino)-3-oxopropyl]-;98N12-5
SMILES:	C(NCCCCCCCCCCCC)(=O)CCN(CCC(NCCCCCCCCCCCC)=O)CCN(CCC(NCCCCCCCCCCCC)=O)CCNCCN(CCC(NCCCCCCCCCCCC)=O)CCC(NCCCCCCCCCCCC)=O
Formula:	C₈₁H₁₆₃N₉O₅
M.Wt:	1343.22
Purity:	>95%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Akinc, A., Goldberg, M., Qin, J., et al. Development of lipidoid-siRNA formulations for systemic delivery to the liver. Mol. Ther. 17(5), 872-879 (2009). 2. Frank-Kamenetsky, M., Grefhorst, A., Anderson, N.N., et al. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc. Natl. Acad. Sci. USA 105(33), 11915-11920 (2008).

Cat. No.	Product name	Field of application
DC70010	98N12-5	98N12-5 is an ionizable cationic lipid. It has been used in combination with other lipids in the generation of lipid nanoparticles (LNPs). LNPs containing 98N12-5 and encapsulating proprotein convertase subtilisin kexin type 9 (PCSK9) siRNA selectively accumulate in the liver and reduce total serum cholesterol levels in mice and rats and serum LDL levels in cynomolgus monkeys.