Calcifediol|cas 19356-17-3|supplier DC Chemicals

Cas No.:	19356-17-3
SMILES:	C[C@H](CCCC(C)(O)C)[C@@H]1[C@](CCC/2)(C)[C@](CC1)([H])C2=CC=C(C[C@H]3O)/C(CC3)=C
Formula:	C₂₇H₄₆O₃
M.Wt:	418.6523
Purity:	>99%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Castoldi A, et al. Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. Eur J Pharm Biopharm. 2016 Nov 22

Description:	Calcifediol is a major circulating metabolite of vitamin D3, acting as a competitive inhibitor with an apparent Ki of 3.9 μM, suppresses PTH secretion and mRNA (ED50=2 nM).
Target:	Human Endogenous Metabolite
In Vitro:	Calcifediol in either liposomes or ethanolic solution has no effect on the release of the proinflammatory cytokine KC from Pseudomonas-infected murine epithelial cells. Treatment of infected, human bronchial 16-HBE cells with Calcifediol liposomes results in a significant reduction in bacterial survival[1].
References:	[1]. Castoldi A, et al. Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. Eur J Pharm Biopharm. 2016 Nov 22

Cat. No.	Product name	Field of application
DCAPI1559	Calcifediol	Calcifediol is a major circulating metabolite of vitamin D3, acting as a competitive inhibitor with an apparent Ki of 3.9 μM, suppresses PTH secretion and mRNA (ED50=2 nM).